1250256-62-2Relevant academic research and scientific papers
Nano-Fe3O4?walnut shell/Cu(ii) as a highly effective environmentally friendly catalyst for the one-potpseudothree-component synthesis of 1,3-oxazine derivatives under solvent-free conditions
Fatemeh Mirjalili, Bi Bi,Tafti, Arefeh Dehghani
, p. 31874 - 31880 (2020)
Fe3O4?walnut shell/Cu(ii) as an eco-friendly bio-based magnetic nano-catalyst was prepared by adding CuCl2to Fe3O4?walnut shell in alkaline medium. A series of 2-aryl/alkyl-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazines were synthesized by the one-potpseudothree-component reaction of β-naphthol, formaldehyde and various amines using nano-Fe3O4?walnut shell/Cu(ii) at 60 °C under solvent-free conditions. The catalyst was removed from the reaction mixture by an external magnet and was reusable several times without any considerable loss of its activity. This protocol has several advantages such as excellent yields, short reaction times, clean and convenient procedure, easy work-up and use of an eco-friendly catalyst.
Enzyme and photoredox sequential catalysis for the synthesis of 1,3-oxazine derivatives in one pot
Zhang, Guo-Yan,Xiang, Yang,Guan, Zhi,He, Yan-Hong
, p. 1937 - 1942 (2017/07/15)
A novel strategy combining visible-light and enzyme catalysis in one pot for the synthesis of 1,3-oxazine derivatives from α- or β-naphthols and ethyl N-aryl glycinates is described for the first time. Various 1,3-oxazine derivatives were prepared with yields of up to 69% under mild reaction conditions by a simple operation. This approach consists of sequential enzymatic hydrolysis and visible-light excited decarboxylation of ethyl N-aryl glycinates, oxidation of α-amino radicals, Mannich reaction, transimination and intramolecular cyclization. This work provides a novel alternative method for the synthesis of 1,3-oxazine derivatives.
Novel and efficient microwave-assisted three component reaction for the synthesis of oxazine derivatives
Bansal, Preeti,Jasuja, Nakueshwar Dutt,Sharma, Gajanand
, p. 2131 - 2138 (2016/10/24)
Oxazine derivatives can be prepared with yield upto 98% within a few minutes by an efficient and novel one pot microwave-assisted three-component reaction from 1-naphthol, various anilines and formalin using montmorillonite as the catalyst. The procedure is very simple, efficient and environmentally friendly as it does not use any toxic auxiliary or solvent. The key advantages of this process are high yields, shorter reaction times, and easy work-up and non-chromatographic method has been used for the purification of products.
An efficient and green method for the synthesis of [1,3]oxazine derivatives catalyzed by thiamine hydrochloride (VB1) in water
Dhakane, Valmik D.,Gholap, Somnath S.,Deshmukh, Umesh P.,Chavan, Hemant V.,Bandgar, Babasaheb P.
, p. 431 - 436 (2014/05/06)
An efficient and convenient synthesis of 1,3-oxazine derivatives has been achieved by the one-pot, multicomponent condensation of α- or β-naphthol, an aniline and formaldehyde using thiamine hydrochloride (VB1) as a versatile biodegradable and reusable catalyst in water as a universal solvent.
Polyethylene glycol (PEG) mediated expeditious synthetic route to 1,3-oxazine derivatives
Shinde, Pravin V.,Kategaonkar, Amol H.,Shingate, Bapurao B.,Shingare, Murlidhar S.
experimental part, p. 915 - 918 (2012/01/11)
Various 1,3-oxazine derivatives were synthesized in high yields, within shorter reaction times using PEG-400 as a safer medium/mediator. This synthetic route is exceedingly easy and avoids the use of acid/base catalysts.
An efficient synthesis of 3, 4-dihydro-3-substituted-2H-naphtho[2, 1-e][1, 3]oxazine derivatives catalyzed by zirconyl(IV) chloride and evaluation of its biological activities
Kategaonkar, Amol H.,Sonar, Swapnil S.,Pokalwar,Kategaonkar, Atul H.,Shingate, Bapurao B.,Shingare, Murlidhar S.
experimental part, p. 1657 - 1660 (2010/10/20)
An efficient and novel one-pot synthesis of new 3,4-dihydro-3-substituted- 2H-naphtho[2, 1-e][1, 3]oxazine derivatives from 1-naphthol, various anilines and formalin at room temperature grinding is presented. The six-membered N,O-heterocyclic skeleton was
