1250404-00-2Relevant academic research and scientific papers
Synthesis of libraries of peptidomimetic compounds containing a 2-oxopiperazine unit in the main chain
Suwal, Sujit,Kodadek, Thomas
, p. 2088 - 2092 (2013)
Peptoid libraries have been shown to be a useful source of protein-binding agents. However, simple linear peptoids lack conformational constraints, which may limit their binding affinity for proteins. Here we report facile chemistry for the assembly of 2-oxopiperazine rings into the main chain of peptoid-like oligomers, thus rigidifying the structure. This modified sub-monomer synthesis is suitable for the creation of high quality combinatorial libraries. The Royal Society of Chemistry 2013.
