Organic and Biomolecular Chemistry p. 2088 - 2092 (2013)
Update date:2022-08-03
Topics: Characterization Deprotection Purification Protection and Activation Biological Evaluation Design and Planning Coupling reactions Synthesis of Amino Acid Building Blocks Library Synthesis
Suwal, Sujit
Kodadek, Thomas
Peptoid libraries have been shown to be a useful source of protein-binding agents. However, simple linear peptoids lack conformational constraints, which may limit their binding affinity for proteins. Here we report facile chemistry for the assembly of 2-oxopiperazine rings into the main chain of peptoid-like oligomers, thus rigidifying the structure. This modified sub-monomer synthesis is suitable for the creation of high quality combinatorial libraries. The Royal Society of Chemistry 2013.
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