Journal of the Chemical Society. Chemical communications p. 760 - 762 (1991)
Update date:2022-08-04
Topics:
Baker, Raymond
Street, Leslie J.
Reeve, Austin J.
Saunders, John
The synthesis of quinuclidine and azanorbornyl pyrazine derivatives has yielded highly potent and efficacious muscarinic agonists; chloro-substitution in the pyrazine ring of the quinuclidine analogue resulted in the formation of a derivative with both enantiomers displaying partial agonist character but, more importantly, functional selectivity at the M1, M2 and M3 sub-types of the muscarinic receptor.
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