125060-66-4

Usage

Uses

Used in Organic Synthesis:
2-N,N-DIMETHYLAMINO-6-IODOPYRAZINE is used as a reagent in organic synthesis for its ability to participate in various chemical reactions, such as cross-coupling reactions and Suzuki-Miyaura coupling. Its reactivity and stability make it a preferred choice for creating new organic compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-N,N-DIMETHYLAMINO-6-IODOPYRAZINE is utilized as a precursor in the synthesis of pharmaceutical drugs. Its unique chemical properties contribute to the development of novel therapeutic agents.
Used in Biological and Medical Imaging:
2-N,N-DIMETHYLAMINO-6-IODOPYRAZINE is employed as a fluorescent dye in biological and medical imaging. Its fluorescent properties allow for the visualization and tracking of biological processes, making it a valuable tool in research and diagnostics.

InChI:InChI=1/C6H8IN3/c1-10(2)6-4-8-3-5(7)9-6/h3-4H,1-2H3

Upstream product

• 58138-79-7 2,6-diiodopyrazine 
• 124-40-3 dimethyl amine 

Downstream Products

• 125059-73-6 (3S,4S)-3-(6-Dimethylamino-pyrazin-2-yl)-1-aza-bicyclo[2.2.1]heptan-3-ol 

Relevant academic research and scientific papers

PYRAZINES, PYRIMIDINES AND PYRIDAZINES USEFUL IN THE TREATMENT OF SENILE DEMENTIA

The present invention provides pyrazines, pyridazines or pyrimidines, or salts or prodrugs thereof, substituted on one of the ring carbon atoms thereof with a non-aromatic azacyclic or azabicyclic ring system; and independently substituted on each of the other ring carbon atoms with a substituent of low lipophilicity or a hydrocarbon substituent; which compounds stimulate central muscarinic acetylcholine receptors and therefore are useful in the treatment of neurological and mental illnesses.

Synthesis and muscarinic activity of quinuclidinyl- and (1- azanorbornyl)pyrazine derivatives

The synthesis and cortical muscarinic activity of a novel series of pyrazine-based agonists is described. Quinuclidine and azanorbornane derivatives were prepared either by reaction of lithiated pyrazines with azabicyclic ketones, followed by chlorination and reduction, or by reaction of the lithium enolate of the azabicyclic ester with 2-chloropyrazines followed by ester hydrolysis and decarboxylation. Substitution at all three positions of the heteroaromatic ring has been explored. Optimal muscarinic agonist activity was observed for unsubstituted pyrazines in the azanorbornane series. The exo-1-azanorbornane 18a is one of the most efficacious and potent centrally active muscarinic agonists known. Studies on the 3-substituted derivatives have provided evidence of the preferred conformation of these ligands for optimal muscarinic activity. Substitution at C6 gave ligands with increased affinity and reduced efficacy. Moving the position of the diazine ring nitrogens to give pyrimidine and pyridazine derivatives resulted in a significant loss of muscarinic activity.