1251570-88-3Relevant articles and documents
An enantioselective approach to 3-substituted pyrrolidines: Asymmetric synthesis for pyrrolidine core of serotonin norepinephrine reuptake inhibitors (SNRIs)
Garg, Yuvraj,Sharma, Pooja,Pandey, Satyendra Kumar
, p. 3493 - 3495 (2017)
A novel and efficient synthetic approach to enantiopure 3-substituted pyrrolidine skeleton from readily available (S)-PMB glycidyl ether as a starting material and its application to the asymmetric synthesis of pyrrolidine core 1 of serotonin norepinephrine reuptake inhibitors (SNRIs) 2 and 3 are described. The synthesis utilizes the organocatalyzed asymmetric Michael addition reaction as key step.
Discovery of a potent, dual serotonin and norepinephrine reuptake inhibitor
Dreyfus, Nicolas,Myers, Jason K.,Badescu, Valentina O.,De Frutos, Oscar,De La Puente, Maria Luz,Ding, Chunjin,Filla, Sandra A.,Fynboe, Karsten,Gernert, Douglas L.,Heinz, Beverly A.,Hemrick-Luecke, Susan K.,Johnson, Kirk W.,Johnson, Michael P.,Lopez, Pilar,Love, Patrick L.,Martin, Laura J.,Masquelin, Thierry,McCoy, Michael J.,Mendiola, Javier,Morrow, Denise,Muhlhauser, Mark,Pascual, Gustavo,Perun, Thomas J.,Pfeifer, Lance A.,Phebus, Lee A.,Richards, Simon J.,Rincon, Juan Antonio,Seest, Eric P.,Shah, Jikesh,Shaojuan, Jia,Simmons, Rosa Maria A.,Stephenson, Gregory A.,Tromiczak, Eric G.,Thompson, Linda K.,Walter, Magnus W.,Weber, Wayne W.,Zarrinmayeh, Hamideh,Thomas, Craig E.,Joshi, Elizabeth,Iyengar, Smriti,Johansson, Anette M.
, p. 560 - 564 (2013)
The objective of the described research effort was to identify a novel serotonin and norepinephrine reuptake inhibitor (SNRI) with improved norepinephrine transporter activity and acceptable metabolic stability and exhibiting minimal drug-drug interaction. We describe herein the discovery of a series of 3-substituted pyrrolidines, exemplified by compound 1. Compound 1 is a selective SNRI in vitro and in vivo, has favorable ADME properties, and retains inhibitory activity in the formalin model of pain behavior. Compound 1 thus represents a potential new probe to explore utility of SNRIs in central nervous system disorders, including chronic pain conditions.
3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS
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Page/Page column 32, (2011/02/15)
In one aspect, the invention relates to compounds of formula I: where R1-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. In a
SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITOR
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Page/Page column 6-7, (2010/11/03)
A serotonin and norepinephrine reuptake inhibitor of the formula: its uses, and methods for its preparation are described.