1251832-81-1

Basic information

• Product Name: (2 - (4 - chlorobenzene) acetylene) benzaldehyde
• Synonyms: (2 - (4 - chlorobenzene) acetylene) benzaldehyde;2-((4-chlorophenyl)ethynyl)benzaldehyde
• CAS NO: 1251832-81-1
• Molecular Formula: C₁₅H₉ClO
• Molecular Weight: 240.68436
• EINECS: -0
• Mol File: 1251832-81-1.mol
• Article Data: 44

Chemical Properties

• Boiling Point: 393.5±27.0 °C(Predicted)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (2 - (4 - chlorobenzene) acetylene) benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (2 - (4 - chlorobenzene) acetylene) benzaldehyde(1251832-81-1)
• EPA Substance Registry System: (2 - (4 - chlorobenzene) acetylene) benzaldehyde(1251832-81-1)

Safety Data

• Hazardous Substances Data: 1251832-81-1(Hazardous Substances Data)

Usage

General Description

(2-(4-chlorobenzyl)acetylene)benzaldehyde is a chemical compound with the formula C16H11ClO. It is a yellow crystalline solid that is insoluble in water but soluble in organic solvents. (2 - (4 - chlorobenzene) acetylene) benzaldehyde is commonly used in the synthesis of other organic compounds, and it has applications in the production of pharmaceuticals, dyes, and other chemical products. It is known for its strong and distinct odor and is used in the fragrance industry as well. Additionally, it has been studied for its potential use in organic electronic devices due to its electronic and optical properties. Overall, (2-(4-chlorobenzyl)acetylene)benzaldehyde has a wide range of potential applications and is an important intermediate in organic synthesis.

Upstream product

• 873-73-4 4-n-chlorophenylacetylene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 38846-64-9 2-ethynylbenzaldehyde 
• 637-87-6 1-Chloro-4-iodobenzene 
• 77123-58-1 2-[2-(trimethylsilyl)ethynyl]benzaldehyde 
• 31357-32-1 α,β-dibromo-p-chlorohydrocinnamic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 1615-02-7 3-(4-chlorophenyl)prop-2-enoic acid 
• 66482-30-2 (Z)-1-bromo-2-(4-chlorophenyl)ethylene 
• 26260-02-6 2-iodobenzaldehyde 

Downstream Products

• 1280219-99-9 (10-(4-chlorophenyl)-3-methylphenanthren-4-yl)(phenyl)methanone 
• 1280219-80-8 1-(2-((4-chlorophenyl)ethynyl)phenyl)-3-phenylprop-2-yn-1-ol 
• 1421694-54-3 2-(2-(4-chlorophenyl)-2-oxoethyl)benzaldehyde 
• 1588973-14-1 C₂₀H₁₇ClO₂ 
• 1588971-91-8 3'-(4-chlorophenyl)-3,4,4'-triiodo-5,5-dimethyl-5H-spiro[furan-2,1'-isochromene] 
• 1588972-64-8 1-(2-((4-chlorophenyl)ethynyl)phenyl)-4-hydroxy-4-methylpent-2-yn-1-one 

Relevant articles and documents

Engaging 1,7-diynes in a photocatalytic Kharasch-type addition/1,5-(SN′′)-substitution cascade toward β-gem-dihalovinyl carbonyls

A new and general photocatalytic Kharasch-type addition/1,5-(SN′′)-substitution cascade of 1,7-diynes with alkyl halides such as BrCCl3and CBr4was reported for the first time, and used to produce 65 hitherto unreported β-gem-dihalovinyl ketones/aldehydes with moderate to excellent yields in a highly regioselective manner. This reaction tolerates a wide scope of substrates, which offers a green and efficient entry to fabricate synthetically important β-gem-dihalovinyl carbonyl scaffolds. Notably, the late-stage application of these resulting β-gem-dihalovinyl carbonyls shows high and unique reactivity profiles and demonstrates the versatility of their derivatization.

Facile preparation of 3-aryl-4-iodoisoquinolines from N-(o-Arylethynyl)benzyl p-toluenesulfonamides with iodine and base

Treatment of N-(o-arylethynyl)benzyl p-toluenesulfonamides with molecular iodine in the presence of NaHCO3 at 60 °C, followed by the reaction with tBuOK at room temperature gave 3-aryl-4-iodoisoquinolines in good yields. 4-Iodo-3-phenylisoquinoline, which is one of the obtained 3-aryl-4-iodoisoquinolines, was further transformed into isoquinoline derivatives smoothly. The present approach is a novel one-pot method for the preparation of 3-aryl-4-iodoisoquinolines from N-(o-arylethynyl)benzyl p-toluenesulfonamides under transition-metal-free conditions.

Modular synthesis of 3-substituted isocoumarinsviasilver-catalyzed aerobic oxidation/6-endoheterocyclization ofortho-alkynylbenzaldehydes

A method involving silver-catalyzed aerobic oxidation/6-endoheterocyclization ofortho-alkynylbenzaldehydes to yield 3-substituted isocoumarins is described. The developed protocol allows convenient access to a range of synthetically useful 3-substituted isocoumarins and related fused heterocyclolactones in good to high yields, using silver tetrafluoroborate as the catalyst, and atmospheric oxygen as the terminal oxidant and the source of endocyclic oxygen. Mechanistic studies suggest the involvement of a free-radical pathway.