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1251843-23-8

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  • 1251843-23-8 Structure

  • Basic information

    1. Product Name: 2-(cyclohexylmethyl)-1-(methoxycarbonyl)piperidine-4-carboxylic acid
    2. Synonyms: 2-(cyclohexylmethyl)-1-(methoxycarbonyl)piperidine-4-carboxylic acid
    3. CAS NO:1251843-23-8
    4. Molecular Formula:
    5. Molecular Weight: 283.368
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1251843-23-8.mol
    9. Article Data: 2

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-(cyclohexylmethyl)-1-(methoxycarbonyl)piperidine-4-carboxylic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-(cyclohexylmethyl)-1-(methoxycarbonyl)piperidine-4-carboxylic acid(1251843-23-8)
    11. EPA Substance Registry System: 2-(cyclohexylmethyl)-1-(methoxycarbonyl)piperidine-4-carboxylic acid(1251843-23-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1251843-23-8(Hazardous Substances Data)

1251843-23-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1251843-23-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,1,8,4 and 3 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1251843-23:
(9*1)+(8*2)+(7*5)+(6*1)+(5*8)+(4*4)+(3*3)+(2*2)+(1*3)=138
138 % 10 = 8
So 1251843-23-8 is a valid CAS Registry Number.

1251843-23-8Relevant articles and documents

Discovery of the fibrinolysis inhibitor AZD6564, acting via interference of a protein-protein interaction

Cheng, Leifeng,Pettersen, Daniel,Ohlsson, Bengt,Schell, Peter,Karle, Michael,Evertsson, Emma,Pahlén, Sara,Jonforsen, Maria,Plowright, Alleyn T.,Bostr?m, Jonas,Fex, Tomas,Thelin, Anders,Hilgendorf, Constanze,Xue, Yafeng,Wahlund, G?ran,Lindberg, Walter,Larsson, Lars-Olof,Gustafsson, David

, p. 538 - 543 (2014/06/09)

A class of novel oral fibrinolysis inhibitors has been discovered, which are lysine mimetics containing an isoxazolone as a carboxylic acid isostere. As evidenced by X-ray crystallography the inhibitors bind to the lysine binding site in plasmin thus preventing plasmin from binding to fibrin, hence blocking the protein-protein interaction. Optimization of the series, focusing on potency in human buffer and plasma clotlysis assays, permeability, and GABAa selectivity, led to the discovery of AZD6564 (19) displaying an in vitro human plasma clot lysis IC50 of 0.44 μM, no detectable activity against GABAa, and with DMPK properties leading to a predicted dose of 340 mg twice a day oral dosing in humans.

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