1252030-42-4

Basic information

• Product Name: C₇H₁₂O₃
• CAS NO: 1252030-42-4
• Molecular Weight: 144.17
• Mol File: 1252030-42-4.mol

Chemical Properties

• CAS DataBase Reference: C₇H₁₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₇H₁₂O₃(1252030-42-4)
• EPA Substance Registry System: C₇H₁₂O₃(1252030-42-4)

Safety Data

• Hazardous Substances Data: 1252030-42-4(Hazardous Substances Data)

Upstream product

• 15568-87-3 5-(hydroxymethylene)-2,2-dimethyl-1,3-dioxan-4,6-dione 
• 75-65-0 tert-butyl alcohol 

Relevant articles and documents

Orthogonally Protected Diaminoterephthalate Scaffolds: Installation of Two Functional Units at the Chromophore

The 2,5-diaminoterephthalate structural motif is a powerful chromophore with remarkable fluorescence properties. Containing two carboxylate and two amino functions, it defines a colored molecular scaffold which allows for orthogonal functionalization with different functional units. Therefore, different applications in life sciences and materials science could be addressed. In this study, the two amino functions were alkylated by reductive amination with side chains carrying amino (orthogonally protected as Boc or Alloc) and carboxylate functions (orthogonally protected as tBu or allyl ester). After sequential deprotections, functional units were introduced by amidation reactions. As three examples, the chromophore was coupled with retinoic acid and fullerene C60 in order to obtain a triad for studying photoinduced electron transfer processes. Furthermore, cyclooctyne and azide moieties were introduced as functional units, allowing for ligation by click reactions. These two clickable groups were applied in combination with maleimide units which are reactive toward thiol residues. The latter dyes define so-called turn on probes, since the fluorescence quantum yields increased by one order of magnitude upon reaction with the molecular target.