15568-87-3

Basic information

• Product Name: (HydroxyMethylene)-Malonic Acid
• Synonyms: (HydroxyMethylene)-Malonic Acid;5-(HydroxyMethylene)-2,2-diMethyl-1,3-dioxane-4,6-dione;ForMyl MeldruM's Acid;5-(hydroxyMethylidene)-2,2-diMethyl-1,3-dioxane-4,6-dione
• CAS NO: 15568-87-3
• Molecular Formula: C₇H₈O₅
• Molecular Weight: 132.07156
• Product Categories: Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 15568-87-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform
• CAS DataBase Reference: (HydroxyMethylene)-Malonic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: (HydroxyMethylene)-Malonic Acid(15568-87-3)
• EPA Substance Registry System: (HydroxyMethylene)-Malonic Acid(15568-87-3)

Safety Data

• Hazardous Substances Data: 15568-87-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 15568-87-3 differently. You can refer to the following data:
1. Meldrum's Acid (M215250) derivative. Antisecretory agent.
2. Meldrum''s Acid (M215250) derivative. Antisecretory agent.

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 122-51-0 orthoformic acid triethyl ester 
• 15568-86-2 5-(ethoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 15568-85-1 5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 123773-67-1 isopropylidene <1-(methylthio)ethylidene>malonate 

Downstream Products

• 123798-25-4 diphenyl hydrogen 2-formylmalonate 
• 34780-29-5 3-oxo-propionic acid ethyl ester 
• 111998-70-0 2-[1-Hydroxy-meth-(E)-ylidene]-malonic acid mono-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester 
• 124595-57-9 l-8-phenylmenthyl hydrogen hydroxymethylenemalonate 
• 24680-50-0 4-methoxy-trans-cinnamaldehyde 
• 14371-10-9 (E)-3-phenylpropenal 
• 1252030-42-4 C₇H₁₂O₃ 
• 108350-21-6 3-oxo-propionic acid tert-butyl ester 
• 187837-96-3 5-fluoro-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 123798-22-1 benzyl hydrogen 2-formylmalonate 
• 108350-22-7 benzyl 3-oxopropanoate 
• 111998-71-1 2-Hydroxymethylene-malonic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester 
• 111998-70-0 2-[1-Hydroxy-meth-(E)-ylidene]-malonic acid mono-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester 
• 111998-70-0 1-menthyl hydrogen hydroxymethylenemalonate 

Relevant articles and documents

Synthesis of Densely Functionalized N-Alkenyl 2-Pyridones via Benzyne-Induced Ring Opening of Thiazolino-Fused 2-Pyridones

We report the synthesis of 6-arylthio-substituted-N-alkenyl 2-pyridones by ring opening of bicyclic thiazolino-2-pyridones with arynes. Varied functionalization was used to investigate scope and substituent influences on reactivity. Selected conditions favor thioether ring opening over [4 + 2] cycloaddition and an unusual aryne incorporating ring expansion. Deuterium labeling was used to clarify observed reactivity. Using the knowledge, we produced drug-like molecules with complex substitution patterns and show how thioether ring opening can be used on scaffolds with competing reactivities.

FLUOROMALONYL HALFTHIOESTERS

The present invention relates to Fluoromalonyl Halfthioesters (F-MAHTs) of formula (I), wherein R1 represents hydrogen, halogen, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl g

Synthetic routes to pyrrolizine-1,5-dione derivatives by flash vacuum pyrolysis of amidomethylene derivatives of Meldrum's acid

Methoxymethylene Meldrum's acid 1 reacts with 5- and 6-membered lactams in refluxing acetonitrile to give the N-substituted products 9-15. If the reactions are continued for extended times, the Meldrum's acid derivatives decompose to provide enamidoesters