125258-56-2

Basic information

• Product Name: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-4-thio-
• CAS NO: 125258-56-2
• Molecular Formula: C31H32N2O6S
• Molecular Weight: 560.671
• Mol File: 125258-56-2.mol

Chemical Properties

• CAS DataBase Reference: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-4-thio-(CAS DataBase Reference)
• NIST Chemistry Reference: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-4-thio-(125258-56-2)
• EPA Substance Registry System: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-4-thio-(125258-56-2)

Safety Data

• Hazardous Substances Data: 125258-56-2(Hazardous Substances Data)

Upstream product

• 3695-77-0 triphenylmethanethiol 
• 135131-54-3 5'-O-(4,4'-Dimethoxytrityl)-4-thiocyanatothymidine 
• 136743-13-0 5'-O-(4,4'-Dimethoxytrityl)-4-(S-p-nitrophenyl)-thiothymidine 
• 139887-85-7 5'-O-dimethoxytrityl-4-S-pivaloyloxymethyl-4-thiothymidine 
• 139887-83-5 4-S-pivaloyloxymethyl-4-thiothymidine 
• 7236-57-9 4-thiothymidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 139887-87-9 3'-O-acetyl-5'-O-dimethoxytrityl-4-S-pivaloyloxymethyl-4-thiothymidine 
• 135131-55-4 5'-O-(4,4'-Dimethoxytrityl)-4-(S-phenyl)-thiothymidine 

Downstream Products

• 657411-17-1 P-methyl-5'-O-dimethoxytritylthymidilyl(3'->5')-4-thiothymidine 
• 135131-55-4 5'-O-(4,4'-Dimethoxytrityl)-4-(S-phenyl)-thiothymidine 
• 135131-56-5 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-methyl-4-pyrrolidin-1-yl-1H-pyrimidin-2-one 
• 117775-85-6 5'-O-(4,4'-dimethoxytrityl)-O⁴-ethylthymidine 
• 117775-90-3 5'-O-(4,4'-dimethoxytrityl)-O⁴-methylthymidine 
• 657411-18-2 5'-O-dimethoxytrityl-3'-O-levulinyl-4-thiothymidine 
• 135131-54-3 5'-O-(4,4'-Dimethoxytrityl)-4-thiocyanatothymidine 

Relevant articles and documents

Synthesis of Dinucleoside Phosphates Containing Sulfur Substituted Nucleobases: 4-Thiouracil, 4-Thiothymine and 6-Mercaptopurine

S-Pivaloyloxymethylation of sulfur substituted nucleobases enables the synthesis in solution of dinucleoside phosphates containing sulfur modified residues such as 4-thiouracil, 4-thiothymine and 6-mercatopurine. Key words: 4-thiouracil; protection; phosphorylation; nucleosides.

The synthesis of oligodeoxynucleotides containing 4-thiothymidine residues

Oligodeoxynucleotides containing 4-thiothymidine residues were obtained using the phosphoramidites of 2 and 3. Treatment with CH3COSK in EtOH was used to introduce the 4-thioketo function at the oligodeoxynucleotide level.

5′-O-(4-4′-dimethylthoxytrityl)-4-thiocyanatothymidine A useful intermediate for the preparation of various 4-substituted thymidine analogues

The thiocyanato group in 5′-O-(4,-4′-dimethoxytrityl)-4-thiocyanatothymidine 2 is easily displaced by a variety if O-, N=- and S-nucleophiles, making this compound a useful intermediate for the preparation of 4-substituted thymidine analogues.