136743-13-0

Basic information

• Product Name: 5'-O-(4,4'-Dimethoxytrityl)-4-(S-p-nitrophenyl)-thiothymidine
• Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-4-(S-p-nitrophenyl)-thiothymidine
• CAS NO: 136743-13-0
• Molecular Weight: 681.766
• Mol File: 136743-13-0.mol

Chemical Properties

• CAS DataBase Reference: 5'-O-(4,4'-Dimethoxytrityl)-4-(S-p-nitrophenyl)-thiothymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4'-Dimethoxytrityl)-4-(S-p-nitrophenyl)-thiothymidine(136743-13-0)
• EPA Substance Registry System: 5'-O-(4,4'-Dimethoxytrityl)-4-(S-p-nitrophenyl)-thiothymidine(136743-13-0)

Safety Data

• Hazardous Substances Data: 136743-13-0(Hazardous Substances Data)

Upstream product

• 142409-76-5 Phenoxy-acetic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[5-methyl-4-(4-nitro-phenylsulfanyl)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 
• 50-89-5 thymidine 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 142409-72-1 Phenoxy-acetic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 135131-54-3 5'-O-(4,4'-Dimethoxytrityl)-4-thiocyanatothymidine 
• 1849-36-1 para-nitrobenzenethiol 

Downstream Products

• 125258-56-2 5'-O-(4,4'-Dimethoxytrityl)-4-thiothymidine 
• 142409-74-3 5'-O-(4,4'-Dimethoxytrityl)-4--thiothymidine 

Relevant articles and documents

Straightforward Preparation and Use in Oligodeoxynucleotide Synthesis of 5'-O-(4,4'-Dimethoxytrityl)-4-Thiothymidine

The title compound was prepared in four steps and 62percent yield from thymidine.After incorporation into synthetic oligodeoxynucleotides, the S-(2-cyanoethyl) group was removed by treatment with DBU in CH3CN to give products containing 4-thiothymidine residues.

The synthesis of oligodeoxynucleotides containing 4-thiothymidine residues

Oligodeoxynucleotides containing 4-thiothymidine residues were obtained using the phosphoramidites of 2 and 3. Treatment with CH3COSK in EtOH was used to introduce the 4-thioketo function at the oligodeoxynucleotide level.