125261-01-0

Upstream product

• 27773-03-1 ethyl 3,3-(ethylenedioxy)-3-phenylpropanoate 
• 78018-47-0 3,3-trimethylenedithio-1-phenyl-1-propanone 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 5764-85-2 Ethyl 3-hydroxy-3-phenylpropanoate 
• 144712-19-6 2-[1,3]Dithian-2-ylmethyl-2-phenyl-[1,3]dioxolane 

Downstream Products

• 205440-44-4 (2R,4R)-N-(2,4,6-trimethoxybenzyl)-2-(2,2-ethylenedioxy-2-phenylethyl)-4-phenyl-1,3-oxazolidine 
• 344357-19-3 (S)-3-[1-Hydroxy-2-(2-phenyl-[1,3]dioxolan-2-yl)-ethyl]-3-methoxymethoxy-4-methyl-4-vinyl-dihydro-furan-2-one 
• 1430751-38-4 tert-butyl 1-benzyl-2-(2-(2-phenyl-1,3-dioxolan-2-yl)ethyl)hydrazinecarboxylate 
• 1430751-40-8 1-benzyl-4-iodo-5-phenyl-1H-pyrazole 
• 39056-60-5 1-benzyl-5-phenyl-1H-pyrazole 
• 1430751-39-5 tert-butyl 1-benzyl-2-(3-oxo-3-phenylpropyl)hydrazinecarboxylate 
• 1430749-03-3 6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-3-(1-benzyl-5-phenyl-1H-pyrazol-4-yl)pyridine-2-carboxylic acid 
• 1428236-13-8 2-(3-cyclopropylallyl)-2-phenyl-1,3-dioxolane 
• 13355-43-6 5-phenyl-1H-pyrrole-2-carboxylic acid ethyl ester 
• 497-89-2 2-[1-methyl-(2S)-piperidin-2-yl]-1-phenyl-(1R)-ethan-1-ol 
• 497-88-1 (-)-sedamine 
• 205440-56-8 (2S,2'R)-N-ethoxycarbonyl-2-(2-hydroxy-2-phenylethyl)piperidine 
• 205440-54-6 (2S,2'S)-N-ethoxycarbonyl-2-(2-hydroxy-2-phenylethyl)piperidine 
• 205440-45-5 (R)-2-[(S)-4-[1,3]Dioxolan-2-yl-1-(2-phenyl-[1,3]dioxolan-2-ylmethyl)-butylamino]-2-phenyl-ethanol 

Relevant academic research and scientific papers

APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES

Disclosed are compounds which inhibit the activity of anti-apoptotic Bc1-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bc1-xL protein.

Synthesis of Hyperolactones A and C

Hyperolactones A (1) and C (3) have been synthesized starting from (S)-malic acid by a straightforward route. The unique spirolactone skeleton was efficiently constructed by one-pot reaction as a key step. The absolute stereochemistry of hyperolactones was unambiguously established by this synthesis.

Masked oxo sulfinimines (N-sulfinyl imines) in the asymmetric synthesis of proline and pipecolic acid derivatives.

[structure: see text]. On addition of Et2AlCN/i-PrOH, masked oxo sulfinimines give alpha-amino nitriles that afford oxo alpha-amino acids on hydrolysis. These amino acids cyclize and are reduced to cis proline and cis pipecolic acids derivatives in high ee and good yield. This new procedure avoids many of the limitations related to the preparation of oxo amino acids from proteinogenic amino acids.