1252671-72-9

Basic information

• Product Name: ethyl 2-benzyl-2-nitrobut-3-ynoate
• Synonyms: ethyl 2-benzyl-2-nitrobut-3-ynoate
• CAS NO: 1252671-72-9
• Molecular Weight: 247.251
• Mol File: 1252671-72-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-benzyl-2-nitrobut-3-ynoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-benzyl-2-nitrobut-3-ynoate(1252671-72-9)
• EPA Substance Registry System: ethyl 2-benzyl-2-nitrobut-3-ynoate(1252671-72-9)

Safety Data

• Hazardous Substances Data: 1252671-72-9(Hazardous Substances Data)

Upstream product

• 16782-23-3 ethyl 3-phenyl-2-nitropropionate 

Downstream Products

• 1252671-77-4 ethyl 2-benzyl-2-(hydroxyamino)but-3-ynoate 
• 1252671-76-3 ethyl 2-amino-2-benzylbut-3-enoate 
• 1252671-75-2 ethyl 2-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-nitro-3-phenylpropanoate 

Relevant articles and documents

Ethynyl-1,2-benziodoxol-3(1H)-one (EBX): An exceptional reagent for the ethynylation of keto, cyano, and nitro esters

Hot alkyne! The in situ generation of ethynyl-1,2-benziodoxol-3(1H)-one (EBX) from a silyl-protected reagent by using TBAF is reported. EBX displayed exceptional acetylene transfer ability onto stabilized enolates (see scheme), even at -78 □°C. The mild reaction conditions allowed the first ethynylation reactions of linear keto, cyano, and nitro esters in high yields to give all-carbon quaternary centers or non-natural amino acids after selective reduction of the nitro group.