1252801-65-2Relevant academic research and scientific papers
Structure Optimization of Gatastatin for the Development of γ-Tubulin-Specific Inhibitor
Chinen, Takumi,Ebisu, Haruna,Hatanaka, Taisei,Hayakawa, Ichiro,Mukaiyama, Minagi,Nagumo, Yoko,Sakakura, Akira,Shintani, Kana,Takao, Daisuke,Usui, Takeo
, p. 1125 - 1129 (2020/07/04)
Gatastatin (O7-benzyl glaziovianin A) is a γ-tubulin-specific inhibitor that is used to investigate γ-tubulin function in cells. We have previously reported that the unsubstituted phenyl ring of the O7-benzyl group in gatastatin is important for γ-tubulin
Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone
Hayakawa, Ichiro,Ikedo, Akiyuki,Chinen, Takumi,Usui, Takeo,Kigoshi, Hideo
, p. 5745 - 5756 (2012/10/29)
Various analogues of glaziovianin A, an antitumor isoflavone, were synthesized, and their biological activities were evaluated. O 7-modified glaziovianin A showed strong cytotoxicity against HeLa S3 cells. Compared to glaziovianin A,
Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells
Ikedo, Akiyuki,Hayakawa, Ichiro,Usui, Takeo,Kazami, Sayaka,Osada, Hiroyuki,Kigoshi, Hideo
scheme or table, p. 5402 - 5404 (2011/02/22)
Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic
