1253-23-2

Basic information

• Product Name: ditoxigenin 3β-formate
• Synonyms: ditoxigenin 3β-formate
• CAS NO: 1253-23-2
• Molecular Weight: 418.53
• Mol File: 1253-23-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ditoxigenin 3β-formate(CAS DataBase Reference)
• NIST Chemistry Reference: ditoxigenin 3β-formate(1253-23-2)
• EPA Substance Registry System: ditoxigenin 3β-formate(1253-23-2)

Safety Data

• Hazardous Substances Data: 1253-23-2(Hazardous Substances Data)

Upstream product

• 2258-42-6 formyl acetic anhydride 
• 545-26-6 gitoxigenin 
• 64-18-6 formic acid 
• 67-64-1 acetone 

Relevant articles and documents

Cardiac Glycosides. 6. Gitoxigenin C16 Acetates, Formates, Methoxycarbonates, and Digitoxosides. Synthesis and Na+, K+ -ATPase Inhibitory Activities

A series of 17 gitoxigenin 16β-formates, acetates, and methoxycarbonates was synthesized, including their 3β-acetates, formates, and digitoxosides.A 16β-formate group was generally found to increase activity 30 times, a 16β-acetate group 9-12 times, while a 16β-methoxycarbonate decreased activity by two-thirds. 3β-Formates and acetates had little effect on activity by themselves, but sometimes reduced the activity-increasing properties of 16β-formates and acetates.A 3β-digitoxoside increases the activity of ditoxigenin by 15 times, but the effect is less ifthe 16β-group is esterified.And finally, a 16-one decreases activity dramatically.These data suggest an important role for C16 esters and possibly the presence of a separate binding site on Na+, K+ -ATPase corresponding to the cardenolide C16 position.