125313-98-6

Basic information

• Product Name: 1H-Pyrrole-2,5-dione, 3-(4-methoxyphenyl)-4-(1-methyl-1H-indol-3-yl)-
• CAS NO: 125313-98-6
• Molecular Formula: C20H16N2O3
• Molecular Weight: 332.359
• Mol File: 125313-98-6.mol

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-2,5-dione, 3-(4-methoxyphenyl)-4-(1-methyl-1H-indol-3-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2,5-dione, 3-(4-methoxyphenyl)-4-(1-methyl-1H-indol-3-yl)-(125313-98-6)
• EPA Substance Registry System: 1H-Pyrrole-2,5-dione, 3-(4-methoxyphenyl)-4-(1-methyl-1H-indol-3-yl)-(125313-98-6)

Safety Data

• Hazardous Substances Data: 125313-98-6(Hazardous Substances Data)

Upstream product

• 6343-93-7 2-(4-methoxyphenyl)acetamide 
• 151490-40-3 methyl 2-(1-methyl-1H-indol-3-yl)-2-oxoacetate 
• 25055-54-3 ethyl 2-(1-methyl-1H-indol-3-yl)-2-oxoacetate 
• 16382-39-1 2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 104-01-8 4-Methoxyphenylacetic acid 
• 603-76-9 1-methylindole 
• 128760-92-9 3-(4-Methoxy-phenyl)-4-(1-methyl-1H-indol-3-yl)-furan-2,5-dione 

Relevant articles and documents

A practical method for the synthesis of indolylaryl- and bisindolylmaleimides

(Chemical Equation Presented) Indolylaryl and indolylheteroarylmaleimides, including bisindolylmaleimides, are easily prepared by the reaction of N-methylindole-3-glyoxylamide with methyl aryl acetates in the presence of potassium tert-butoxide in THF.

A new one step synthesis of maleimides by condensation of glyoxylate esters with acetamides

Bisphenyl, bisheteroaryl, indolylaryl and indolylcycloalkyl maleimides are prepared in one step and 67-99% yield by condensation of glyoxylate esters with acetamides using a 1.0 M solution of potassium tert-butoxide in THF. The mechanism of the reaction is discussed.

Inhibitors of Protein Kinase C. 1. 2,3-Bisarylmaleimides

The design and synthesis of a series of novel inhibitors of protein kinase C (PKC) is described.These 2,3-bisarylmaleimides were derived from the structural lead provided by the indolocarbazoles, staurosporine and K252a.Optimum activity required the imide NH, both carbonyl groups, and the olefinic bond of the maleimide ring. 2,3-Bisindolylmaleimides were the most active, and the potency of these was improved by a chloro substituent at the 5-position of one indole ring (compound 28, IC50 0.11 μM).In a series of (phenylindolyl)maleimides, nitro compound 74 was most active (IC50 0.67 μM).Naphthalene 19 and benzothiophene 21 showed greater than 100-fold selectivity for inhibition of PKC over the closely related cAMP-dependent protein kinase (PKA).

Substituted pyrroles

Compounds of the formula STR1 wherein R1, R2, R3, R4, R5, R6, R7, X and Y have the signficance given in the description, are useful in the control or prevention of inflammatory, immunological, bronchopulmonary or cardiovascular disorders.