125314-13-8 Usage
Uses
CP21R7 is a potent and selective inhibitor of GSK3β.
Biological Activity
cp21r7 is a potent and selective inhibitor of gsk3β.the glycogen synthase kinase-3β (gsk-3β), a serine/threonine, is a ubiquitous kinase that participates in a multitude of cellular processes, such as cell membrane-to-nucleus signaling, gene transcription, translation, cytoskeletal structuring and cell cycle progression and survival [1].
in vitro
cp21r7 was an inhibitor of gsk3β and pkcα with the ic50 values of 1.8 and 1900 nm, respectively [1]. in the human reporter cell line, cp21r7 potently activated canonical wnt signallingeven at the dose of 1 μm, with highest activity seen at 3 μm [2]. in human ipscs exposed to n2b27 medium, supplemented with 1 μm gsk3β inhibitor cp21r7 strongly upregulated the expression of t (also known as brachyury, t/bry), a meso-endoderm marker expressed in the primitive streak [2].
references
[1] gong l, hirschfeld d, tan y c, et al. discovery of potent and bioavailable gsk-3β inhibitors[j]. bioorganic & medicinal chemistry letters, 2010, 20(5): 1693-1696.[2] ciampi o, iacone r, longaretti l, et al. generation of functional podocytes from human induced pluripotent stem cells[j]. stem cell research, 2016, 17(1): 130-139.
Check Digit Verification of cas no
The CAS Registry Mumber 125314-13-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,3,1 and 4 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 125314-13:
(8*1)+(7*2)+(6*5)+(5*3)+(4*1)+(3*4)+(2*1)+(1*3)=88
88 % 10 = 8
So 125314-13-8 is a valid CAS Registry Number.
125314-13-8Relevant articles and documents
Design and synthesis of (aza)indolyl maleimide-based covalent inhibitors of glycogen synthase kinase 3β
Yang, Zhimin,Liu, Hui,Pan, Botao,He, Fengli,Pan, Zhengying
, p. 4127 - 4140 (2018/06/12)
As an important kinase in multiple signal transduction pathways, GSK-3β has been an attractive target for chemical probe discovery and drug development. Compared to numerous reversible inhibitors that have been developed, covalent inhibitors of GSK-3β are
3-INDOLYL-4-PHENYL-1H-PYRROLE-2,5-DIONE DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3BETA
-
, (2008/06/13)
-
Substituted pyrroles
-
, (2008/06/13)
Compounds of the formula STR1 wherein R1, R2, R3, R4, R5, R6, R7, X and Y have the signficance given in the description, are useful in the control or prevention of inflammatory, immunological, bronchopulmonary or cardiovascular disorders.
