1253429-01-4

Upstream product

• 1253428-85-1 3-(1-ethyl-3-methylpyrazol-5-yl)-2-(4-tertbutylphenyl)-3-hydroxy-acrylonitrile 
• 3282-30-2 pivaloyl chloride 
• 20577-61-1 methyl 2,4-dioxopentanoate 
• 25016-17-5 3-methyl-1H-pyrazole-5-carboxylic acid methyl ester 
• 88398-73-6 methyl 1-ethyl-3-methyl-1H-5-pyrazolecarboxylate 
• 3288-99-1 4-tert-butylbenzyl cyanide 

Relevant academic research and scientific papers

Synthesis, Acaricidal Activity, and Structure-Activity Relationships of Pyrazolyl Acrylonitrile Derivatives

A series of novel pyrazolyl acrylonitrile derivatives was designed, targeting Tetranychus cinnabarinus, and synthesized. Their structures were identified by combination of1H NMR,13C NMR, and MS spectra. The structures of compounds 18 and 19 were further confirmed by X-ray diffraction. Extensive greenhouse bioassays indicated that compound 19 exhibits excellent acaricidal activity against all developmental stages of T. cinnabarinus, which is better than the commercialized compounds cyenopyrafen and spirodiclofen. It was shown that the acute toxicity of compounds 19 to mammals is quite low. The structure-activity relationships are also discussed.

Preparation method of pyrazolyl acrylonitrile compound

The invention belongs to the field of organic synthesis, and concretely relates to a preparation method of a pyrazolyl acrylonitrile compound. A pyrazole carboxylic ester compound and p-tert-butylphenylacetonitrile are shown in a general formula (II), in the existence of an organic solvent and alkali, a reaction is carried out at 60-160 DEG C, 2-(4-(tert-butyl)phenyl)-1-(1-ethyl-3-methyl-1hydrogen-5-pyrazolyl)-2-cyan vinyl alcohol sodium salt or kali salt is obtained as shown in a general formula (III), a reaction is directly carried out between the obtained compound (III) and pivaloyl chloride at 60-160 DEG C, and the pyrazolyl acrylonitrile compound as shown in a general formula (I) is obtained. The method has the advantages of high yield of the target compound, low 'three wastes (waste gas, waste water and industrial residue)' discharge, and simple operation; and the method is suitable for large scale industrial production.

Pyrazolyl Acrylonitrile Compounds and Uses Thereof

A kind of pyrazolyl acrylniitrile compounds represented by the structures of formula I or stereoisomers thereof are disclosed in the present invention. Where in: R1 is selected from the group of substituents consisting of H, C1-Csub