125354-13-4

Basic information

• Product Name: 10-deacetylisotaxol
• Synonyms: 10-deacetylisotaxol
• CAS NO: 125354-13-4
• Molecular Weight: 811.883
• Mol File: 125354-13-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 10-deacetylisotaxol(CAS DataBase Reference)
• NIST Chemistry Reference: 10-deacetylisotaxol(125354-13-4)
• EPA Substance Registry System: 10-deacetylisotaxol(125354-13-4)

Safety Data

• Hazardous Substances Data: 125354-13-4(Hazardous Substances Data)

Upstream product

• 33069-62-4 paclitaxel 
• 114977-25-2 C₄₉H₅₅Cl₆NO₁₈ 
• 114915-16-1 C₄₄H₄₇Cl₆NO₁₆ 
• 125354-12-3 C₅₁H₅₁Cl₆NO₁₇ 
• 133524-69-3 C₃₈H₄₅NO₁₂ 
• 98-88-4 benzoyl chloride 
• 95603-45-5 7,10-di(2,2,2-trichloroethyloxy-carbonyl)-13-cinnamoyl-10-deacetyl baccatin III 

Relevant articles and documents

Taxol Structure-Activity Relationships: Synthesis and Biological Evaluation of 10-Deoxytaxol

10-Deoxytaxol 2 was prepared from taxol (1) in four steps via the intermediate dienone 5b; the key reaction in the sequence is a Yarovenko reagent-mediated dehydration at the C-10 hydroxyl group.Compound 2 was found to possess comparable antitumor activity with respect to taxol.This confirms that the functional group at C-10 in taxol is not involved in receptor binding.

Relationships between the structure of taxol analogues and their antimitotic activity

A variety of synthetic analogues of taxol, a naturally occurring antitumor diterpene, were examined for their potency to inhibit microtubule disassembly. For some of the compounds, the in vitro cytotoxic properties showed a good correlation with the tubulin assay. This structure-activity relationship study shows that inhibition of microtubule disassembly is quite sensitive to the configuration at C-2' and C-3'. A correlation between the conformation of the side chain at C-13 and the activity is suggested. Of all the compounds examined, one of the most potent in inhibiting microtubule disassembly and in inhibiting murine P388 leukemic cells, N-debenzoyl-N-tert-(butoxycarbonyl)-10-deacetyltaxol, named taxotere, was selected for evaluation as a potential anticancer agent.