125354-12-3

Basic information

• Product Name: C₅₁H₅₁Cl₆NO₁₇
• Synonyms: C₅₁H₅₁Cl₆NO₁₇
• CAS NO: 125354-12-3
• Molecular Weight: 1162.68
• Mol File: 125354-12-3.mol

Chemical Properties

• CAS DataBase Reference: C₅₁H₅₁Cl₆NO₁₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₁H₅₁Cl₆NO₁₇(125354-12-3)
• EPA Substance Registry System: C₅₁H₅₁Cl₆NO₁₇(125354-12-3)

Safety Data

• Hazardous Substances Data: 125354-12-3(Hazardous Substances Data)

Upstream product

• 201856-53-3 (3R,4S)-3-(1-ethoxyethoxy)-4-(phenyl)-N-benzoyl-2-azetidinone 
• 132127-31-2 3-Triisopropylsilyloxy-4-phenylazetidin-2-one 
• 201856-48-6 (3R,4S)-3-<((R^*)-1'-ethoxyethyl)oxy>-4-phenyl-2-azetidinone 
• 132127-34-5 (3R,4S)-3-hydroxy-4-phenylazetidin-2-one 
• 100-52-7 benzaldehyde 
• 17599-61-0 N-benzylidene-1,1,1-trimethylsilanamine 
• 144629-55-0 2'-EE-10-Deacetyl-7,10-bis(trichloroethoxycarbonyl)-taxol 
• 114977-25-2 C₄₉H₅₅Cl₆NO₁₈ 
• 98-88-4 benzoyl chloride 
• 114915-16-1 C₄₄H₄₇Cl₆NO₁₆ 

Downstream Products

• 125354-13-4 10-deacetylisotaxol 

Relevant articles and documents

New and efficient approaches to the semisynthesis of taxol and its C-13 side chain analogs by means of β-lactam synthon method

Highly efficient chiral ester enolate-imine condensation giving 3-hydroxy-4-aryl-β-lactams with excellent enantiomeric purity is successfully applied to the asymmetric synthesis of the enantiomerically pure taxol C-13 side chain, N-benzoyl-(2R,3S)-3-phenyl-isoserine and its analogs. (3R,4S)-N-benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone readily derived from the 3-hydroxy-4-phenyl-β-lactam is coupled with protected baccatin IIIs, followed by deprotection to give optically pure taxol and 10-deacetyl-7,10-bis(Troc)-taxol in good yields. Fully assigned 1H, 13C, and 2D (COSY and HETCOR) NMR spectra of taxol thus synthesized are shown and discussed.