1253955-08-6

Basic information

• Product Name: methyl 2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)acetate
• Synonyms: methyl 2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)acetate
• CAS NO: 1253955-08-6
• Molecular Weight: 336.547
• Mol File: 1253955-08-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 381.1±22.0 °C(Predicted)
• Density: 0.960±0.06 g/cm3(Predicted)
• CAS DataBase Reference: methyl 2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)acetate(1253955-08-6)
• EPA Substance Registry System: methyl 2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)acetate(1253955-08-6)

Safety Data

• Hazardous Substances Data: 1253955-08-6(Hazardous Substances Data)

Upstream product

• 73401-74-8 4-hydroxymethylphenylacetic acid 
• 13737-36-5 4-bromophenylacetic acid 
• 622-47-9 4-tolylacetic acid 
• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 
• 155380-11-3 methyl 4-(hydroxymethyl)phenylacetate 

Downstream Products

• 1253955-09-7 methyl 3-(1,3-dioxoisoindolin-2-yl)-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propanoate 
• 1253955-14-4 tert-butyl 2-(4-(hydroxymethyl)phenyl)-3-(isoquinolin-6-ylamino)-3-oxopropylcarbamate 
• 1253955-13-3 tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-((triisopropylsilyloxy)methyl)phenyl)propylcarbamate 
• 1253955-11-1 3-(1,3-dioxoisoindolin-2-yl)-N-(isoquinolin-6-yl)-2-(4-((triisopropylsilyloxy)methyl)phenyl)propanamide 
• 1253955-10-0 2-(2-carboxy-2-(4-((triisopropylsilyloxy)methyl)phenyl)ethylcarbamoyl)benzoic acid 

Relevant articles and documents

SS-AMINO ACID DERIVATIVE, KINASE INHIBITOR AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, AND USE OF THE SAME

A compound represented by Formula (I), a pharmaceutically acceptable salt or ester, hydrate, solvate or crystalline form thereof is provided: The compound represented by Formula (I) is a β-amino acid derivative, and in Formula (I): X is a single bond or O; Y is NH or C=O; Z is C=O, C=S, NH, W is C or N; A is a single bond, O, OH, OCH2, a heterocycle or N3; R1 is H or F; R2 is H, F, OH, CF3, CH2OH, CHO or ; R3 is H; n is 0 or 1; and m is 0 or 1.

BETA-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS

Disclosed are alpha-axyl-beta-axmno isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the invention are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, and diseases characterized by abnormal growth, such as cancers. The invention further provides compositions containing isoquinoline amide compounds.

DUAL-ACTION INHIBITORS AND METHODS OF USING SAME

Provided are compounds, compositions, and methods for treating diseases and conditions wherein an inhibitor of a kinase, such as rho kinase (ROCK), and an inhibitor of one or more of the monoamine transporters, such as NET or SERT, act in concert to improve the condition.