1253955-46-2

Upstream product

• 1253955-44-0 benzyl 2-(4-(triisopropylsiloxy)phenyl)acetate 
• 100-39-0 benzyl bromide 
• 27727-37-3 benzyl p-hydroxyphenylacetate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1253955-45-1 benzyl 3-cyano-2-((triisopropylsilyloxy)phenyl)propanoate 

Downstream Products

• 1253955-47-3 4-(tert-butoxycarbonylamino)-2-(4-(triisopropylsilyloxy)phenyl)butanoic acid 

Relevant academic research and scientific papers

AMINO-BENZOISOTHIAZOLE AND AMINO-BENZOISOTHIADIAZOLE AMIDE COMPOUNDS

Provided herein are amino-benzoisothiazole and benzoisothiadiazole amide compounds. In particular, provided herein are compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds provided herein are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, retinal diseases such as acute macular degeneration (AMD) and diabetic macular edema (DME), diseases and conditions characterized by inflammatory processes, cardiovascular diseases, and diseases characterized by abnormal growth, such as cancers. Also provided are compositions (e.g., pharmaceutical compositions) comprising the compounds provided herein.

DUAL-ACTION INHIBITORS AND METHODS OF USING SAME

Provided are compounds, compositions, and methods for treating diseases and conditions wherein an inhibitor of a kinase, such as rho kinase (ROCK), and an inhibitor of one or more of the monoamine transporters, such as NET or SERT, act in concert to improve the condition.