1254-07-5

Upstream product

• 477-51-0 deoxypodophyllotoxin 
• 133906-63-5 (+/-)-2-Hydroxymethyl-6,7-methylenedioxy-4-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-3-naphthoic acid 
• 6258-32-8 (dl)-5-(3,4,5-trimethoxyphenyl)-8a,9-dihydrofuro[3′,4’:6,7]-naphtho[2,3-d][1,3]dioxol-6(8H)-one 
• 82792-91-4 6,7-methylenedioxy-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydro-2,3-naphthoic anhydride 
• 128014-53-9 (+)-γ-apopodophyllic acid 
• 120-57-0 piperonal 
• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 
• 82792-81-2 1-(3,4,5-trimethoxyphenyl)-5,6-methylenedioxy-1,3-dihydrobenzothiophene-2,2-dioxide 
• 82792-83-4 -3,4-methylenedioxybenzyl alcohol 
• 82792-85-6 5,6-methylenedioxy-1-(3,4,5-trimethoxyphenyl)-1,3-dihydrobenzothiophene 
• 6642-34-8 6-bromopiperonyl alcohol 

Downstream Products

• 24150-39-8 deoxypicropodophyllin 
• 140147-76-8 deoxypicropodophyllinic acid methyl ester 
• 171483-28-6 (5R,6S,7R)-7-Formyl-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester 
• 477-51-0 (5S,5aS,8aR)-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3′,4’:6,7]naphtho[2,3-d][1,3]-dioxol-6(5aH)-one 
• 477-51-0 (+/-)-Isopicrodesoxypodophyllotoxin 
• 83023-41-0 (+)-Isodeoxypicropodophyllin 
• 477-51-0 deoxypodophyllotoxin 

Relevant academic research and scientific papers

Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia

Twelve lignan derivatives were synthesized from deoxypodophyllotoxin isolated from Hernandia nymphaeifolia. Cytotoxicity evaluation against cholangiocarcinoma, KKU-100, and HepG2 cell lines showed that compounds 3, 9, 10, and 13 exhibited stronger cytotoxicity than the starting material, 1, with IC50 ranging from 0.42 to 2.01 μM. Compound 10 displayed interesting activity by showing IC50 values of 0.75 and 0.46 μM against KKU-100 and HepG2 cell lines, respectively. From these observation, 10 seems to be useful as a lead compound for the development of anticancer agents.

Efficient Asymmetric Syntheses of Naturally Occurring Lignan Lactones Using Catalytic Asymmetric Hydrogenation as a Key Reaction

Optically pure (R)-arylmethylsuccinic acid mono-methyl esters were obtained efficiently by using the catalytic asymmetric hydrogenation of arylidenesuccinic acid monoesters with a rhodium(I) complex of a chiral bisphosphine, (4S,5S)-MOD-DIOP.Asymmetric total syntheses of some naturally occurring lignans, (+)-collinusin, (-)-deoxypodophyllotoxin, and (+)-neoisostegane, were achieved via several steps from (R)-γ-butyrolactones as key intermediates obtained by reduction of (R)-arylmethylsuccinic acid mono methyl-esters.

The Synthesis of Lignans and Related Structures using Quinodimethanes and Isobenzofurans: Approaches to the Podophyllins

Novel routes to 1-aryl-5,6-dialkoxy-1,3-dihydrobenzothiophene 2,2-dioxides (13) and to the corresponding benzofuran (8) have been developed; these species yield quinodimethanes (12) via thermal extrusion of SO2 and isobenzofurans (5c) in an acid-cat