128014-53-9

Upstream product

• 668-01-9 (+)-γ-Apopicropodophyllin 

Downstream Products

• 477-51-0 deoxypodophyllotoxin 
• 1254-07-5 (5S,6S,7R)-7-Hydroxymethyl-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid 
• 83023-41-0 (+)-Isodeoxypicropodophyllin 

Relevant academic research and scientific papers

Asymmetric total synthesis of (-)-deoxypodophyllotoxin

An efficient total synthesis of (-)-deoxpophyllotoxin has been achieved by employing the asymmetric hydrogenation of α-piperonylidene-succinic acid half ester with a rhodium(I) complex of (S,S)-MOD-DIOP as a key step.

Efficient Asymmetric Syntheses of Naturally Occurring Lignan Lactones Using Catalytic Asymmetric Hydrogenation as a Key Reaction

Optically pure (R)-arylmethylsuccinic acid mono-methyl esters were obtained efficiently by using the catalytic asymmetric hydrogenation of arylidenesuccinic acid monoesters with a rhodium(I) complex of a chiral bisphosphine, (4S,5S)-MOD-DIOP.Asymmetric total syntheses of some naturally occurring lignans, (+)-collinusin, (-)-deoxypodophyllotoxin, and (+)-neoisostegane, were achieved via several steps from (R)-γ-butyrolactones as key intermediates obtained by reduction of (R)-arylmethylsuccinic acid mono methyl-esters.