125403-32-9Relevant academic research and scientific papers
New cytotoxic selenoderivatives of guaianolides
Barbetti, Paolo,Fardella, Giuseppe,Chiappini, Ione,Scarcia, Vito,Furlani Candiani, Ariella
, p. 299 - 306 (1989)
A series of 13-phenylselenoderivatives of natural and semisynthetic guaianolides were prepared and their cytotoxicity tested in vitro against KB cell cultures.Generally the presence of the 13-Se-phenyl group led to an increased bioactivity (ID50) supporting the hypothesis that it may act as a "masked" α-methylene-γ-lactone group.
