New cytotoxic selenoderivatives of guaianolides

Article abstract of DOI:10.1016/0223-5234(89)90013-5

A series of 13-phenylselenoderivatives of natural and semisynthetic guaianolides were prepared and their cytotoxicity tested in vitro against KB cell cultures.Generally the presence of the 13-Se-phenyl group led to an increased bioactivity (ID₅₀) supporting the hypothesis that it may act as a "masked" α-methylene-γ-lactone group.