European Journal of Medicinal Chemistry p. 299 - 306 (1989)
Update date:2022-08-04
Topics:
Barbetti, Paolo
Fardella, Giuseppe
Chiappini, Ione
Scarcia, Vito
Furlani Candiani, Ariella
A series of 13-phenylselenoderivatives of natural and semisynthetic guaianolides were prepared and their cytotoxicity tested in vitro against KB cell cultures.Generally the presence of the 13-Se-phenyl group led to an increased bioactivity (ID50) supporting the hypothesis that it may act as a "masked" α-methylene-γ-lactone group.
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