1254199-54-6

Basic information

• Product Name: (S)-tert-butyl 4-(2-fluoro-5-nitrophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate
• Synonyms: (S)-tert-butyl 4-(2-fluoro-5-nitrophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate
• CAS NO: 1254199-54-6
• Molecular Weight: 380.376
• Mol File: 1254199-54-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-tert-butyl 4-(2-fluoro-5-nitrophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl 4-(2-fluoro-5-nitrophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate(1254199-54-6)
• EPA Substance Registry System: (S)-tert-butyl 4-(2-fluoro-5-nitrophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate(1254199-54-6)

Safety Data

• Hazardous Substances Data: 1254199-54-6(Hazardous Substances Data)

Upstream product

• 1076160-56-9 (R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide 
• 887913-52-2 (methylamino)thioxomethylcarbamic acid t-butyl ester 
• 1075230-62-4 (R)-2-methylpropane-2-sulfinic acid [1-(2-fluoro-5-nitrophenyl)-(E)-ethylidene]amide 
• 1254199-42-2 methyl (S)-3-(((R)-tert-butylsulfinyl)amino)-3-(2-fluoro-5-nitrophenyl)butanoate 
• 4248-19-5 tert-butyl carbazate 
• 1213413-42-3 (S)-3-amino-3-(2-fluoro-5-nitro-phenyl)-butyric acid methyl ester 
• 445-27-2 2'-Fluoroacetophenone 
• 79110-05-7 1-(2-fluoro-5-nitrophenyl)ethanone 

Downstream Products

• 1254199-70-6 (S)-tert-butyl 4-(5-amino-2-fluorophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate 
• 1286278-36-1 (S)-tert-butyl 4-(5-bromo-2-fluorophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate 

Relevant articles and documents

Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease

Verubecestat 3 (MK-8931), a diaryl amide-substituted 3-imino-1,2,4-thiadiazinane 1,1-dioxide derivative, is a high-affinity β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor currently undergoing Phase 3 clinical evaluation for the treat

DIHYDROPYRIMIDINONES FOR USE AS BACE2 INHIBITORS

This invention relates to dihydropyrimidinones of the formula (I), wherein X and R1 to R7 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are BACE2 inhibitors