1254223-76-1

Basic information

• Product Name: (MeO)2Tr-OAc
• Synonyms: (MeO)2Tr-OAc
• CAS NO: 1254223-76-1
• Molecular Weight: 362.425
• Mol File: 1254223-76-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (MeO)2Tr-OAc(CAS DataBase Reference)
• NIST Chemistry Reference: (MeO)2Tr-OAc(1254223-76-1)
• EPA Substance Registry System: (MeO)2Tr-OAc(1254223-76-1)

Safety Data

• Hazardous Substances Data: 1254223-76-1(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 40615-35-8 4,4'-dimethoxytrityl alcohol 
• 10534-59-5 tetrabutylammonium acetate 

Downstream Products

• 1277097-06-9 5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxyuridine 
• 1277097-07-0 C₅₅H₅₃N₃O₁₀ 
• 1277097-09-2 5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine 
• 1277097-10-5 N₄-benzoyl-5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine 
• 188411-06-5 N₄-benzoyl-5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-[N,N-diisopropyl-N-cyanoethyl]phosphoramidite 
• 23669-79-6 DMT-dU 
• 104375-88-4 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine 
• 93778-57-5 9-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 

Relevant articles and documents

Improved synthesis of 5-hydroxymethyl-2′-deoxycytidine phosphoramidite using a 2′-deoxyuridine to 2′-deoxycytidine conversion without temporary protecting groups

5-Hydroxymethylcytosine has recently been characterized as the 'sixth base' in human DNA. To enable research on this DNA modification, we report an improved method for the synthesis of 5-hydroxymethyl-2′-deoxycytidine (5-HOMedC) phosphoramidite for site-specific incorporation into oligonucleotides. To minimize manipulations we employed a temporary protecting group-free 2′-deoxyuridine to 2′-deoxycytidine conversion procedure that utilizes phase transfer catalysis. The desired 5-HOMedC phosphoramidite is obtained in six steps and 24% overall yield from 2′-deoxyuridine.