125446-66-4

Upstream product

• 104823-09-8 1-{(S)-1-Methyl-2-[(E)-(R)-1-phenyl-ethylimino]-cyclohexyl}-pentan-3-one 
• 352695-16-0 (1R_.E)-N-(2-methylcyclohexylidene)-1-phenylethanamine 
• 583-60-8 2-Methylcyclohexanone 
• 1629-58-9 4-penten-3-one 

Downstream Products

• 58193-60-5 (S)-1,1,4a-trimethyl-3,4,4a,5,6,7-hexahydronaphthalen-2(1H)-one 
• 3203-30-3 (2S,4aS)-1,1,4a-trimethyl-1,2,3,4,4a,5,6,7-octahydronaphthalen-2-ol 

Relevant academic research and scientific papers

Enantioselective syntheses of (2S,4AS,8aR)-1,1-4a-trimethyldecahydronaphthalen-2-ol[(-)-TMD], (4aS,8aR)-5,58a-trimethyloctahydronaphthalen-2(1H)-one, and (-)-Polywood, through Michael-type reaction of chiral imines

The title compounds 6, 15, and 17 have been synthesized in a straightforward way in good yields and high enantiomeric excesses by the chiral imines method, leading to building-blocks 2 and 10, followed by a few conventional steps.

TETRAHYDRONAPHTHALENE DERIVATIVES USEFUL AS NRF2 ACTIVATORS

Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use as Nrf2 activators and for their production.