1254688-09-9

Basic information

• Product Name: 4-(4-(aminomethyl)-1H-1,2,3-triazol-1-yl)benzoic acid
• Synonyms: 4-(4-(aminomethyl)-1H-1,2,3-triazol-1-yl)benzoic acid
• CAS NO: 1254688-09-9
• Molecular Weight: 218.215
• Mol File: 1254688-09-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(4-(aminomethyl)-1H-1,2,3-triazol-1-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-(aminomethyl)-1H-1,2,3-triazol-1-yl)benzoic acid(1254688-09-9)
• EPA Substance Registry System: 4-(4-(aminomethyl)-1H-1,2,3-triazol-1-yl)benzoic acid(1254688-09-9)

Safety Data

• Hazardous Substances Data: 1254688-09-9(Hazardous Substances Data)

Upstream product

• 6427-66-3 4-azidobenzoic acid 
• 2450-71-7 Propargylamine 

Relevant articles and documents

Fragment-Based Discovery of a Qualified Hit Targeting the Latency-Associated Nuclear Antigen of the Oncogenic Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8

The latency-associated nuclear antigen (LANA) is required for latent replication and persistence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. It acts via replicating and tethering the virus episome to the host chromatin and exerts other functions. We conceived a new approach for the discovery of antiviral drugs to inhibit the interaction between LANA and the viral genome. We applied a biophysical screening cascade and identified the first LANA binders from small, structurally diverse compound libraries. Starting from a fragment-sized scaffold, we generated optimized hits via fragment growing using a dedicated fluorescence-polarization-based assay as the structure-activity-relationship driver. We improved compound potency to the double-digit micromolar range. Importantly, we qualified the resulting hit through orthogonal methods employing EMSA, STD-NMR, and MST methodologies. This optimized hit provides an ideal starting point for subsequent hit-to-lead campaigns providing evident target-binding, suitable ligand efficiencies, and favorable physicochemical properties.

'Click' assembly of selective inhibitors for MAO-A

In this Letter, an efficient strategy for the fast construction of 108 compounds library was developed using click chemistry. The fingerprint of inhibitory activity toward MAO-A/B against this library was obtained, and four hit compounds were identified as selective inhibitors toward MAO-A. Docking study was carried out to demonstrate the binding mode between a9 and MAO-A/B, and the result reveals that a9 localized in the 'aromatic cage' and oriented to establish π-π stacking interactions with Tyr407, Tyr444 and FAD in MAO-A rather than in MAO-B.