125476-64-4Relevant academic research and scientific papers
Preparation method of 3-oxetane carboxylic acid
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Paragraph 0071-0073, (2018/08/03)
The invention provides a preparation method of 3-oxetane carboxylic acid. The preparation method is characterized by carrying out hydrolytic esterification reaction, hydrogen pulling reaction and reduction reaction by taking 3-hydroxypropionitrile as a raw material, thus obtaining 2-benzyloxymethyl-1,3-propanediol; carrying out cyclization reaction, debenzylation reaction and oxidation reaction on2-benzyloxymethyl-1,3-propanediol, thus obtaining 3-oxetane carboxylic acid. According to the preparation method of 3-oxetane carboxylic acid, provided by the invention, a key intermediate 2-benzyloxymethyl-1,3-propanediol can be prepared just through three-steps reaction by taking 3-hydroxypropionitrile as the raw material, and 3-oxetane carboxylic acid can be prepared just through six-steps reaction in a final integral route, so that the reaction route is greatly shortened, and reaction steps are reduced; compared with a preparation method requiring ten-steps reaction in the prior art, theyield is higher, the operation is easy, and industrial production can be favorably realized.
Enantioselective Saponification of Substituted, Achiral 3-Acyloxy-propionates with Lipases: Synthesis of Chiral Derivatives of "Tris(hydroxymethyl)methane"
Ehrler, Juerg,Seebach, Dieter
, p. 379 - 388 (2007/10/02)
Ethyl 3-hydroxy-2-(hydroxymethyl)propionate (11) was synthesized with an overall yield of 40percent starting from the pentaerythritol derivative 5,5-bis(hydroxymethyl)-1,3-dioxane (7).Both OH-groups of 11 were acetylated (ethanoyl, propanoyl, butanoyl, he
