623-72-3Relevant articles and documents
Method for preparing 3-hydracrylic acid ester derivative
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Paragraph 0053-0055, (2022/01/04)
The invention discloses a method for preparing a 3-hydracrylic acid ester derivative, which comprises the step of in the presence of an alcohol compound and a hydrodeoxygenation catalyst, reacting glyceric acid with hydrogen and the alcohol compound to obtain the 3-hydracrylic acid ester derivative, wherein the hydrodeoxygenation catalyst is a mixture of a supported metal catalyst and at least one supported metal oxide catalyst and/or at least one supported heteropolyacid catalyst. The method disclosed by the invention is green and environment-friendly, and the yield of the 3-hydracrylic acid ester derivative is high.
Producing method of 3-hydroxypropanoate
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Paragraph 0031; 0032, (2019/05/15)
The invention relates to a producing method of 3-hydroxypropanoate. The problems that a catalyst is complex in preparation and low in activity in the prior art are mainly solved. According to the producing method of the 3-hydroxypropanoate, with the presence of a cobalt salt, ligand and a cocatalyst, oxirane, synthesis gas and alcohol react to obtain the 3-hydroxypropanoate, wherein the cobalt salt is one of cobalt phosphate, cobalt sulfate, cobalt acetate, cobalt chloride, cobalt carbonate, cobalt nitrate, cobalt hydroxide, cobalt oxide and cobalt oxalate, the ligand is N-containing ligand, and the cocatalyst is metal powder or a carrier-loaded metal element. By means of the technical scheme, the technical problem is well solved, and the method can be used for industrial production of the3-hydroxypropanoate.
Preparation method of 3-oxetane carboxylic acid
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Paragraph 0065-0069, (2018/08/03)
The invention provides a preparation method of 3-oxetane carboxylic acid. The preparation method is characterized by carrying out hydrolytic esterification reaction, hydrogen pulling reaction and reduction reaction by taking 3-hydroxypropionitrile as a raw material, thus obtaining 2-benzyloxymethyl-1,3-propanediol; carrying out cyclization reaction, debenzylation reaction and oxidation reaction on2-benzyloxymethyl-1,3-propanediol, thus obtaining 3-oxetane carboxylic acid. According to the preparation method of 3-oxetane carboxylic acid, provided by the invention, a key intermediate 2-benzyloxymethyl-1,3-propanediol can be prepared just through three-steps reaction by taking 3-hydroxypropionitrile as the raw material, and 3-oxetane carboxylic acid can be prepared just through six-steps reaction in a final integral route, so that the reaction route is greatly shortened, and reaction steps are reduced; compared with a preparation method requiring ten-steps reaction in the prior art, theyield is higher, the operation is easy, and industrial production can be favorably realized.
Immobilization of Carbonylcobalt Catalyst by Poly(4-vinylpyridine) (P4VP) through N→Co Coordination Bonds: The Promotional Effect of Pyridine and the Reusability of Polymer Catalyst
Liu, Yu-Bing,Wang, Yi-Ning,Lu, Hai-Meng,Liang, Shuang,Xu, Bo-Lian,Fan, Yi-Ning
supporting information, p. 3159 - 3164 (2016/11/29)
A carbonylcobalt catalyst, immobilized by poly(4-vinylpyridine) (P4VP) through N→Co coordination bonds, has been prepared by solvothermal method. It has been revealed that the pyridine fragments in the polymer catalyst act not only as promoters to improve the catalytic performance of the carbonylcobalt catalyst for alkoxycarbonylation of ethylene oxide to methyl 3-hydroxypropanoate but also as stabilizers to enhance the reusability of the polymer catalyst. Furthermore, the polymer catalyst could be easily separated by filtration and reused with only a slight loss of catalytic efficiency.
Highly active Cu/SiO2 catalysts for hydrogenation of diethyl malonate to 1,3-propanediol
Ding, Tongmei,Tian, Hengshui,Liu, Jichang,Wu, Wenbin,Yu, Jintao
, p. 484 - 493 (2016/04/20)
Cu/SiO2 catalysts prepared by the ammonia evaporation method were applied to hydrogenation of diethyl malonate to 1,3-propanediol. The calcination temperature played an important role in the structural evolution and catalytic performance of the Cu/SiO2 catalysts, which were systematically characterized by N2 adsorption-desorption, inductively coupled plasma-atomic emission spectroscopy, N2O chemisorption, X-ray diffraction, Fourier transform infrared spectroscopy, H2 temperature-programmed reduction, transmission electron microscopy, and X-ray photoelectron spectroscopy. When the Cu/SiO2 catalyst was calcined at 723 K, 90.7% conversion of diethyl malonate and 32.3% selectivity of 1,3-propanediol were achieved. Compared with Cu/SiO2 catalysts calcined at other temperatures, the enhanced catalytic performance of the Cu/SiO2 catalyst calcined at 723 K can be attributed to better dispersion of copper species, larger cupreous surface area and greater amount of copper phyllosilicate, which results in a higher ratio of Cu+/Cu0. The synergetic effect of Cu0 and Cu+ is suggested to be responsible for the optimum activity.
Pharmacophore elucidation of phosphoiodyn A - Potent and selective peroxisome proliferator-activated receptor β/δ agonists with neuroprotective activity
Kinarivala, Nihar,Suh, Ji Ho,Botros, Mina,Webb, Paul,Trippier, Paul C.
supporting information, p. 1889 - 1893 (2016/04/05)
We report the pharmacophore of the peroxisome proliferator-activated receptor δ (PPARδ) agonist natural product phosphoiodyn A is the phosphonate core. Synthesis of simplified phosphonate esters 13 and 15 provide structurally novel, highly selective and potent PPARδ agonists (EC50 = 78 and 112 nM, respectively). Further, both compounds demonstrate significant neuroprotective activity in an in vitro cellular model indicating that phosphonates may be an effective novel scaffold for the design of therapeutics for the treatment of neurodegenerative disorders.
METHODS FOR PRODUCING ALKYL HYDROXYALKANOATES
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Paragraph 00096; 00097, (2015/05/05)
Methods and systems for producing alkyl hydroxyalkanoate from hydroxy carboxylic acid recovery bottoms. The methods generally comprise the steps of obtaining a hydroxy carboxylic acid recovery bottom, adding a mono-alcohol to the hydroxy carboxylic acid recovery bottom to obtain a first mixture, heating the first mixture in the presence of a catalyst to form a reaction product, distilling the reaction product, and recovering an alkyl hydroxyalkanoate fraction.
METHODS OF MANUFACTURING DERIVATIVES OF β-HYDROXYCARBOXYLIC ACIDS
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Page/Page column 7-9, (2008/06/13)
Preparation of derivatives of β-hydroxycarboxylic acid, including β-hydroxycarboxylic acid esters, α,β-unsaturated carboxylic acids, esters of α,β-unsaturated carboxylic acid, and alkoxy derivatives.
Enantiomerically pure tetrahydro-5-oxo-2-furancarboxylic esters from dialkyl 2-oxoglutarates
Drioli, Sara,Nitti, Patrizia,Pitacco, Giuliana,Tossut, Laura,Valentin, Ennio
, p. 2713 - 2728 (2007/10/03)
Enantiomerically pure tetrahydro-5-oxo-2-furancarboxylic esters can be prepared either by enzymatic resolution of the racemic γ-lactones themselves or by bioreduction with baker's yeast of dialkyl 2-oxoglutarates and subsequent cyclization of the resulting dialkyl 2-hydroxyglutarates. The best results were obtained by the former route, by which the desired compounds were isolated in high enantiomeric excess. Bioreductions were less satisfactory. In fact the hydroxyester intermediates were initially formed as racemic mixtures and their final enantiomeric enrichment was reached by asymmetric destruction, occurring in the bioreaction medium, however at the same time large amounts of alkyl 4-hydroxybutanoates were formed as side products.
Erythromycin compounds
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, (2008/06/13)
Compounds of the formula STR1 wherein X and X' form C=O or C=NOR, R is selected from the group consisting of hydrogen, heterocycle, alkyl, alkenyl, alkynyl, all optionally substituted, or X is STR2 Ra and Rb are hydrogen or a hydrocarbon group or form together with the nitrogen a heterocycle, or with A forms a 9-N, 11-O ring, and X' is hydrogen, --Y and Y' have the same definition as X and X', B is hydrogen or OR4, R4 is hydrogen or forms together with A a carbonate or a carbamate, A forms with C a double bond or A is OR'4, R'4 is hydrogen or forms together with B a carbonate or STR3 R2 is alkyl or --CONH2, --CONHCOR11 or --CONHSO2 R11, R11 is a hydrocarbon up to 18 carbon atoms, R3 is hydrogen, STR4 and Z is hydrogen or a carboxylic acid remainder and their non-toxic, pharmaceutically acceptable acid addition salts, their preparation and intermediates useful as antibiotics.
