1254836-23-1

Basic information

• Product Name: 3-(4-fluorophenyl)furan-2-carbaldehyde
• Synonyms: 3-(4-fluorophenyl)furan-2-carbaldehyde
• CAS NO: 1254836-23-1
• Molecular Weight: 190.174
• Mol File: 1254836-23-1.mol

Chemical Properties

• CAS DataBase Reference: 3-(4-fluorophenyl)furan-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-fluorophenyl)furan-2-carbaldehyde(1254836-23-1)
• EPA Substance Registry System: 3-(4-fluorophenyl)furan-2-carbaldehyde(1254836-23-1)

Safety Data

• Hazardous Substances Data: 1254836-23-1(Hazardous Substances Data)

Upstream product

• 13546-87-7 (E)-4-((furan-2-ylmethylene)amino)-N,N-dimethylaniline 
• 225916-39-2 2-(4-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane 
• 98-01-1 furfural 
• 1765-93-1 4-fluoroboronic acid 
• 14757-78-9 3-bromofurfural 

Relevant articles and documents

Lanthanide(III)-Catalyzed Synthesis of trans-Diaminocyclopentenones from Substituted Furfurals and Secondary Amines via a Domino Ring-Opening/4π-Electrocyclization Pathway

A strategy toward the synthesis of trans-4,5-diaminocyclopent-2-enones is described. This core motif is embedded in the marine sponge derived alkaloids agelamadin B and nagelamide J. A variety of 2-substituted trans-4,5-diaminocyclopent-2-enones were synthesized in good to quantitative yields using lanthanide(III) catalysis. The products were formed exclusively as the trans-diastereomers via a mechanism in which the C4-C5 bond formation occurs through a 4π-conrotatory electrocyclization. The precursor 3-substituted furfurals can be readily accessed using palladium(0)-catalyzed cross-coupling between 3-bromofurfural and boronic acids, trifluoroborate salts, or alkynes.

Ruthenium-Catalyzed C-H Arylation and Alkenylation of Furfural Imines with Boronates

A Ru0-catalyzed direct C-H arylation and alkenylation of furfural imines with aryl- or alkenyl-boronates, in the presence of benzylideneacetone as a sacrificial hydride acceptor, is disclosed. This reaction provides access, after hydrolysis, to C3-arylated or vinylated furfural derivatives, and thus valorizes these relevant building-blocks obtained from lignocellulosic biomass. This approach, involving C-H activation by a Ru0/RuII, cycle offers several advantages, notably simple, mild and neutral reaction conditions.

2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXAMIDES

Disclosed are sEH inhibitors of formula (I), wherein the variables are as defined herein, as well as pharmaceutical compositions, kits, and articles of manufacture that contain such compounds. Also disclosed are methods and intermediates for making the compounds and the use of such compounds to treat various disorders, diseases, and conditions associated with sEH.