125494-99-7

Upstream product

• 124887-27-0 (1-Benzyloxy-3-hydroxymethyl-4-methoxy-naphthalen-2-yl)-cyclopentyl-methanol 
• 100-39-0 benzyl bromide 
• 183203-85-2 9-Hydroxy-4-methoxy-3H-naphtho[2,3-c]furan-1-one 
• 68726-79-4 4,9-dihydroxynaphtho<2,3-c>furan-1(3H)-one 
• 123373-22-8 4,9-Dimethoxy-3H-naphtho[2,3-c]furan-1-one 
• 124887-24-7 3-<1-cyclopentyl-1-<<(1,1-dimethylethyl)dimethylsilyl>-oxy>methyl>-2-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-methyl>-1-methoxy-4-naphthalenol 
• 124887-26-9 1-Benzyloxy-2-[(tert-butyl-dimethyl-silanyloxy)-cyclopentyl-methyl]-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-methoxy-naphthalene 

Downstream Products

• 1026372-60-0 (9-benzyloxy-1-hydroxy-4-methoxy-1,3-dihydro-naphtho[2,3-c]furan-1-yl)-acetic acid tert-butyl ester 
• 308277-85-2 (9-benzyloxy-4-methoxy-1,3-dihydro-naphtho[2,3-c]furan-1-yl)-acetic acid 

Relevant academic research and scientific papers

Synthesis of the functionalized tricyclic core of lactonamycin by oxidative dearomatization.

[reaction: see text] We report in this Letter a synthesis of the densely oxygenated CDEF ring system (27) corresponding to that found in the recently discovered antibiotic lactonamycin. The key steps in the synthesis consist of an intramolecular Wessely oxidative lactonization of acid 18, followed by a hydroxyl-directed epoxidation of enol ether 21.

Studies of the total synthesis of fredericamycin a. Preparation of key partial structures and development of an intermolecular alkyne-chromium carbene complex benzannulation cyclization approach to the ABCD(E) ring system

A study illustrating factors effecting the cyclization mode and regioselectivity of the alkyne-chromium carbene complex benzannulation cyclization reaction is detailed in development of a synthetic approach to the fredericamycin A ABCD(E) ring system.