1255151-20-2Relevant articles and documents
Efficient synthesis of novel oxime analogues of the hormone 1α, 25-dihydroxyvitamin D3Paper
Li, Hongliang,Fang, Zhijie,Dai, Huanran,Zhang, Hengrui,Liu, Yanan
, p. 368 - 372 (2015)
Calcitriol analogues which contained an oxime in the side chain were synthesised in five steps from an intermediate 22-nor Ketone. The key intermediate enones were synthesised by the Wittig-Horner olefination and Wittig olefination respectively. Reduction
Enantiomeric impurity PY2 of tacalcitol and preparation method and application thereof
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, (2018/05/30)
The invention discloses an enantiomeric impurity PY2 of tacalcitol, i.e., (1 alpha, 3 beta, 5Z, 7E, 24S)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol, and a preparation method thereof, and belongsto the technical field of chemical pharmaceutical. The high-purity relevant impurity PY2 of the tacalcitol, which is disclosed by the invention, can be used as an impurity standard substance in the tacalcitol finished product detection analysis so as to promote accurate positioning and nature determination of the tacalcitol finished product detection analysis on the impurity and benefit reinforcement of control on the impurity, thereby improving quality of a tacalcitol finished product. The method provided by the invention has the advantages that the raw materials are cheap and easy to obtain, the operation is simple, the reproducibility is good in and the HPLC (High Performance Liquid Chromatography) purity is greater than or equal to 99.5%.