57333-95-6

Basic information

• Product Name: 1alpha,24(S)-Dihydroxyvitamin D₃
• Synonyms: 1alpha,24(S)-Dihydroxyvitamin D₃
• CAS NO: 57333-95-6
• Molecular Weight: 416.645
• Mol File: 57333-95-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1alpha,24(S)-Dihydroxyvitamin D₃(CAS DataBase Reference)
• NIST Chemistry Reference: 1alpha,24(S)-Dihydroxyvitamin D₃(57333-95-6)
• EPA Substance Registry System: 1alpha,24(S)-Dihydroxyvitamin D₃(57333-95-6)

Safety Data

• Hazardous Substances Data: 57333-95-6(Hazardous Substances Data)

Usage

Type

Synthetic analog of vitamin D3

Properties

+ Potent antiproliferative and differentiation-inducing activities
+ Highly potent modulator of cell proliferation and differentiation
+ Inhibits the growth of various cancer cells
+ Promotes bone mineralization
+ Regulates calcium and phosphorus metabolism

Therapeutic potential

+ Treatment of various autoimmune and inflammatory diseases
+ More stable and has a longer half-life than natural form of vitamin D3
+ Potential candidate for therapeutic use in various diseases.

Upstream product

• 1255151-20-2 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3′-isopropyl-3′-oxypropyl)-9,10-secopregna-5(E),7(E),10(19)-triene 
• 112828-13-4 (5E,7E)-(1S,3R,20S)-1,3-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al 
• 266686-81-1 (6S)- and (6R)-SO₂ adducts of 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(S)-formyl-9,10-secopregna-5,7(E),10⁽¹⁹⁾-triene 
• 170081-46-6 (6S)- and (6R)-SO₂ adducts of 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-9,10-secoergosta-5(E),7(E),10⁽¹⁹⁾,22(E)-tetraene 
• 115540-28-8 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-9,10-secoergosta-5(E),7(E),10⁽¹⁹⁾,22(E)-tetraene 
• 115540-27-7 1(S),3(R)-3-(tert-butyldimethylsilyl)-9,10-secoergosta-5(E),7(E),10⁽¹⁹⁾,22(E)-tetraene-1-ol 

Relevant articles and documents

Enantiomeric impurity PY2 of tacalcitol and preparation method and application thereof

The invention discloses an enantiomeric impurity PY2 of tacalcitol, i.e., (1 alpha, 3 beta, 5Z, 7E, 24S)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol, and a preparation method thereof, and belongsto the technical field of chemical pharmaceutical. The high-purity relevant impurity PY2 of the tacalcitol, which is disclosed by the invention, can be used as an impurity standard substance in the tacalcitol finished product detection analysis so as to promote accurate positioning and nature determination of the tacalcitol finished product detection analysis on the impurity and benefit reinforcement of control on the impurity, thereby improving quality of a tacalcitol finished product. The method provided by the invention has the advantages that the raw materials are cheap and easy to obtain, the operation is simple, the reproducibility is good in and the HPLC (High Performance Liquid Chromatography) purity is greater than or equal to 99.5%.