125520-61-8

Basic information

• Product Name: 1,2,5-Oxadiazole-3-carboxylic acid, 4-phenyl-, 5-oxide
• CAS NO: 125520-61-8
• Molecular Formula: C9H6N2O4
• Molecular Weight: 206.158
• Mol File: 125520-61-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2,5-Oxadiazole-3-carboxylic acid, 4-phenyl-, 5-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,5-Oxadiazole-3-carboxylic acid, 4-phenyl-, 5-oxide(125520-61-8)
• EPA Substance Registry System: 1,2,5-Oxadiazole-3-carboxylic acid, 4-phenyl-, 5-oxide(125520-61-8)

Safety Data

• Hazardous Substances Data: 125520-61-8(Hazardous Substances Data)

Upstream product

• 125520-60-7 3-phenyl-4-furoxancarboxamide 
• 104-54-1 3-Phenylpropenol 
• 125520-58-3 methyl 4-phenyl-3-furoxancarboxylate 
• 157066-36-9 2-Oxy-4-phenyl-furazan-3-carbonyl chloride 
• 125520-55-0 3-carboxy-4-phenyl-1,2,5-oxadiazole 2-oxide 
• 125520-54-9 4-hydroxyimino-3-phenyl-5(4H)-isoxazolone 
• 135733-30-1 3-(hydroxymethyl)-4-phenylfuroxan 
• 135733-31-2 4-(hydroxymethyl)-3-phenylfuroxan 
• 135733-35-6 3-phenyl-4-furoxancarbaldehyde 

Downstream Products

• 3672-49-9 phenyl(5-phenyl-1,2-oxazol-3-yl)methanone 
• 86340-05-8 3-benzoyl-5-phenylisoxazole oxime 
• 118898-87-6 2-phenyl-2-hydroxyiminoacetonitrile oxide 
• 125520-64-1 methyl 3-phenyl-4-furoxancarboxylate 

Relevant articles and documents

Pharmacochemistry of the furoxan ring: Recent developments

In the present work recent results obtained in the pharmacochemistry of the furoxan system are reported. In particular, after a brief description of the salient points of the furoxan chemistry, the synthesis and the properties of a series of Nifedipine and Prazosin analogues, containing this heterocyclic system, are described. Since we observed that a few furoxan derivatives are able to elicit both a dose-dependent rise in platelet cGMP levels and to promote a dose-dependent inhibition of AA-induced [Ca++] rise, and that many substituted furoxans show potent vasodilating and antiaggregatory activity, the possibility of using the furoxan system as a lead in the design of new vasodilators is also discussed.

Phenylfuroxancarboxylic Acids and Their Derivatives

Synthesis and structure of the two isomeric furoxanecarboxylic acids 3 and 14 and a few of their derivatives 10-13, 15, 16 is reported. 1,3-dipolar cycloaddition reactions of the product obtained by thermal decomposition of 4-phenyl-3-furoxancarboxylic acid and thermal equilibration of furoxan derivatives are also discussed.