86340-05-8

Upstream product

• 3672-49-9 phenyl(5-phenyl-1,2-oxazol-3-yl)methanone 
• 118898-87-6 2-phenyl-2-hydroxyiminoacetonitrile oxide 
• 536-74-3 phenylacetylene 
• 125520-54-9 4-hydroxyimino-3-phenyl-5(4H)-isoxazolone 
• 125520-61-8 3-phenyl-4-furoxancarboxylic acid 
• 125520-55-0 3-carboxy-4-phenyl-1,2,5-oxadiazole 2-oxide 
• 104-54-1 3-Phenylpropenol 
• 135733-30-1 3-(hydroxymethyl)-4-phenylfuroxan 
• 135733-31-2 4-(hydroxymethyl)-3-phenylfuroxan 
• 135733-35-6 3-phenyl-4-furoxancarbaldehyde 
• 135733-34-5 4-phenylfuroxan-3-carboxaldehyde 

Downstream Products

• 3672-49-9 phenyl(5-phenyl-1,2-oxazol-3-yl)methanone 

Relevant academic research and scientific papers

Pharmacochemistry of the furoxan ring: Recent developments

In the present work recent results obtained in the pharmacochemistry of the furoxan system are reported. In particular, after a brief description of the salient points of the furoxan chemistry, the synthesis and the properties of a series of Nifedipine and Prazosin analogues, containing this heterocyclic system, are described. Since we observed that a few furoxan derivatives are able to elicit both a dose-dependent rise in platelet cGMP levels and to promote a dose-dependent inhibition of AA-induced [Ca++] rise, and that many substituted furoxans show potent vasodilating and antiaggregatory activity, the possibility of using the furoxan system as a lead in the design of new vasodilators is also discussed.

Phenylfuroxancarboxylic Acids and Their Derivatives

Synthesis and structure of the two isomeric furoxanecarboxylic acids 3 and 14 and a few of their derivatives 10-13, 15, 16 is reported. 1,3-dipolar cycloaddition reactions of the product obtained by thermal decomposition of 4-phenyl-3-furoxancarboxylic acid and thermal equilibration of furoxan derivatives are also discussed.

Heterocyclic Rearrangements. Synthesis and Reactivity of Oximes of Some 3-Acylisoxazoles. A Reinvestigation

The oximation reaction of some 3-acylisoxazoles with hydroxylamine hydrochloride and the geometry of the product oximes were reinvestigated. 3-Benzoylisoxazoles gave mixtures of (E)- and (Z)-isomers, whereas 3-acetylisoxazoles gave (E)-isomers only.The base-induced rearrangement of 3-acylisoxazole oximes to 1,2,5-oxadiazoles (furazans) was reinvestigated and was shown to depend on the geometry of the oximes since, when treated with aqueous potassium hydroxide, only (Z)-oximes readily rearranged.On the basis of our findings, some discrepancies in the literature have been corrected.