125520-73-2

Upstream product

• 539-87-7 oxocan-2-one 
• 6110-37-8 methyl 2,4-dimethoxy-6-methylbenzoate 
• 38315-25-2 methyl 7-iodoheptanoate 
• 14565-11-8 methyl 7-hydroxyheptanoate 
• 7149-90-8 2,4-dimethoxy-6-methyl-benzaldehyde 
• 3686-57-5 2,4-dimethoxy-6-methylbenzoic acid 
• 130877-73-5 methyl 2,4-dimethoxy-6-(7-methoxycarbonyl) heptyl benzoate 
• 130877-74-6 methyl 2,4-dimethoxy-6-(p-tolylsulfonyl) methyl benzoate 
• 502-42-1 cycloheptanone 
• 125520-71-0 (7R)-1-Chlor-7-(1-ethoxyethoxy)octan 
• 125520-70-9 <(3R)-1-(3'-Chlorpropyl)-4-(1''-ethoxyethoxy)pentyl>phenylsulfon 
• 4179-19-5 1,3-dimethoxy-5-methylbenzene 
• 13321-73-8 2-bromo-1,5-dimethoxy-3-methylbenzene 
• 130877-77-9 (+)(R,S) methyl 2,4-dimethoxy-6-<8-hydroxy-9-(p-tolylsulfinyl) nonyl> benzoate 

Downstream Products

• 125520-74-3 (R)-6-(8'-Hydroxynonyl)-2,4-dimethoxybenzoesaeure-methylester 
• 32885-82-8 (R)-de-O-Methyllasiodiplodin 

Relevant academic research and scientific papers

Catalytic enantioselective synthesis of macrolides via asymmetric alkylation

Catalytic enantioselective syntheses of the macrolides (R)-(-) phoracantholide and (R)-(+) lasiodiplodin have been achieved. Stereochemistry was introduced in using an arene chromium tricarbonyl derived catalyst, which mediated the enantioselective additi

Asymmetric synthesis of orsellinic acid type macrolides: The example of lasiodiplodin

The asymmetric synthesis of both enantiomers of methyl lasiodiplodin is described. The chiral centers were created in the very last steps of the synthesis by asymmetric induction of a chiral sulfoxide group.

Synthesis of (R)-Lasiodiplodin from Polyhydroxybutyric Acid

The twelve-membered macrolide (R)-lasiodiplodin (1), a fungal metabolite of Botrysdiplodia theobromae, has been synthesized in a nine-step procedure. (R)-1,3-Butanediol (6), which is easily available by reductive depolymerization of the biopolymer polyhydroxybutyric acid (PHB), proves itself as a suitable enantiomerically pure building block.