125533-10-0

Basic information

• Product Name: 2-(4-methylcyclohexyl)-1-phenylethan-1-one
• Synonyms: 2-(4-methylcyclohexyl)-1-phenylethan-1-one
• CAS NO: 125533-10-0
• Molecular Weight: 216.323
• Mol File: 125533-10-0.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-methylcyclohexyl)-1-phenylethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methylcyclohexyl)-1-phenylethan-1-one(125533-10-0)
• EPA Substance Registry System: 2-(4-methylcyclohexyl)-1-phenylethan-1-one(125533-10-0)

Safety Data

• Hazardous Substances Data: 125533-10-0(Hazardous Substances Data)

Upstream product

• 71-43-2 benzene 
• 934-67-8 trans-4-methylcyclohexanecarboxylic acid 
• 3937-49-3 (trans-4-methylcyclohexyl)methanol 
• 55930-23-9 trans-4-methylcyclohexanecarbonyl chloride 
• 78507-26-3 trans-1-(bromomethyl)-4-methylcyclohexane 
• 7132-93-6 (trans-4-methyl-cyclohexyl)-acetic acid 
• 78507-27-4 trans-4-methylcyclohexylmethyl cyanide 
• 589-91-3 p-methylcyclohexanol 
• 98-85-1 1-Phenylethanol 
• 7731-28-4 cis-4-methylcyclohexanol 
• 98-86-2 acetophenone 

Downstream Products

• 87002-25-3 [2-(4-Methyl-cyclohexyl)-ethyl]-benzene 

Relevant articles and documents

Catalytic Cross-Coupling of Secondary Alcohols

Herein, an unprecedented ruthenium(II) catalyzed direct cross-coupling of two different secondary alcohols to β-disubstituted ketones is reported. Cyclic, acylic, symmetrical, and unsymmetrical secondary alcohols are selectively coupled with aromatic benzylic secondary alcohols to provide ketone products. A single catalyst oxidizes both secondary alcohols to provide selectively β-disubstituted ketones to broaden the scope of this catalytic protocol. Number of bond activation and bond formation reactions occur in selective sequence via amine-amide metal-ligand cooperation operative in Ru-MACHO catalyst. The product-induced diastereoselectivity was also observed. Kinetic and deuterium labeling experiments suggested that the aliphatic secondary alcohols undergo oxidation reaction faster than benzylic secondary alcohols, selectively assimilating to provide the cross-coupled products. Reactions are sensitive to steric hindrance. This new C-C bond forming methodology requires low catalyst load and catalytic amount of base. Notably, the reaction produces H2 and H2O as the only byproducts making the protocol greener, atom economical and environmentally benign.

Ruthenium-Catalyzed α-Alkylation of Ketones Using Secondary Alcohols to β-Disubstituted Ketones

An assortment of aromatic ketones was successfully functionalized with a variety of unactivated secondary alcohols that serve as alkylating agents, providing β-disubstituted ketone products in good to excellent yields. Remarkably, challenging substrates such as simple acetophenone derivatives are effectively alkylated under this ruthenium catalysis. The substituted cyclohexanol compounds displayed product-induced diastereoselectivity. Mechanistic studies indicate the involvement of the hydrogen-borrowing pathway in these alkylation reactions. Notably, this selective and catalytic C-C bond-forming reaction requires only a minimal load of catalyst and base and produces H2O as the only byproduct, making this protocol attractive and environmentally benign.

1-(TRANS-4 prime -N-ALKYLCYCLOHEXYL)-2-(4 double prime -CYANOPHENYL)ETHANES - A NEW SERIES OF STABLE NEMATOGENS OF POSITIVE DIELECTRIC ANISOTROPY.

The synthesis and some important properties of the 1-(trans-4 prime -n-alkylcyclohexyl)-2-(4 double prime -cyanophenyl)ethanes - where n-alkyl equals C//1 to C//7 - are described.