125536-69-8

Upstream product

• 17082-61-0 1,2-bis(trimethylsiloxy)cyclobutene 
• 98-86-2 acetophenone 
• 108-86-1 bromobenzene 
• 765-69-5 2-Methylcyclopentane-1,3-dione 
• 3674-77-9 2-methyl-2-phenyl-1,3-dioxolane 

Downstream Products

• 1016989-14-2 C₁₂H₁₆O₂ 
• 1383003-66-4 (2S,4R,5S)-4-((S)-[1,1'-biphenyl]-4-yl(hydroxy)methyl)-5-ethyl-2-methyl-2-phenylcyclopentane-1,3-dione 
• 1383003-37-9 2-methyl-2-phenylcyclopent-4-ene-1,3-dione 
• 1383003-56-2 (2R,4S)-4-ethyl-2-methyl-2-phenylcyclopentane-1,3-dione 

Relevant academic research and scientific papers

An efficient approach to γ-alkylidene γ-butyrolactones: Application to the syntheses of pyridazinones and diazocinones

The efficient phototransformation of a variety of spirodiones 3 to γ- alkylidene γ butyrolactones 4 and their application to the syntheses of biologically useful pyridazinones 14 and diazocinones 15 are described.

Silver-Catalyzed Asymmetric Desymmetrization of Cyclopentenediones via [3 + 2] Cycloaddition with α-Substituted Isocyanoacetates

A highly selective and practical asymmetric Ag(I) catalyst system has been developed for the [3 + 2] cycloaddition reactions between isocyanoacetates and cyclopentenediones. The current Ag(I) catalyst system tolerates moisture and air and readily utilizes class III solvents such as EtOAc and acetone. The development of on demand generation of an active chiral catalyst in the presence of isocyanides paves a way to the efficient asymmetric preparation of bicyclic pyrrolidines with four stereogenic centers, including two quaternary centers in 80-97% ee.

Auto-Tandem Catalysis: PdII-Catalysed Dehydrogenation/Oxidative Heck Reaction of Cyclopentane-1,3-diones

A PdII catalyst system has been used to successfully catalyse two mechanistically distinct reactions in a one-pot procedure: dehydrogenation of 2,2-disubstituted cyclopentane-1,3-diones and the subsequent oxidative Heck coupling. This auto-tand

Oxidative Heck desymmetrisation of 2,2-disubstituted cyclopentene-1,3-diones

Oxidative Heck couplings have been successfully developed for 2,2-disubstituted cyclopentene-1,3-diones. The direct coupling onto the 2,2-disubstituted cyclopentene-1,3-dione core provides a novel expedient way of enantioselectively desymmetrising all-carbon quaternary centres. This journal is

Comparative reductive desymmetrization of 2,2-disubstituted-cycloalkane-1,3-diones

Reductive desymmetrization of 2-methyl-2-substituted-cycloalkane-1,3-diones can be effected using either NaBH4 in DME or lithium tri-tert-butoxyaluminum hydride (LTBA) in THF at -60 °C. The former is a new approach that offers slightly greater

Lewis acid catalyzed geminal acylation reaction of ketones with 1,2-bis((trimethylsilyl)oxy)cyclobutene: Direct formation of 2,2-disubstituted 1,3-cyclopentanediones

Ketones reacted with 1,2-bis((trimethylsilyl)oxy)cyclobutene (1) under catalysis by boron trifluoride etherate to yield 2,2-disubstituted 1,3-cyclopentanedione products via silylated cyclobutanone intermediates in a two-step, one-pot process. In many inst

A Convenient Synthesis of Spirodione and 2,2-Disubstituted Cyclopentane-1,3-dione System

An efficient, one pot strategy for the synthesis of spirodione and 2,2-disubstituted cyclopentane-1,3-dione has been developed by using ketals and 1,2-disilyloxycyclobutene in the presence of excess BF3*Et2O.