125552-98-9

Basic information

• Product Name: Benzamide, N-[(2-methylphenyl)methyl]-
• CAS NO: 125552-98-9
• Molecular Formula: C15H15NO
• Molecular Weight: 225.29
• Mol File: 125552-98-9.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[(2-methylphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[(2-methylphenyl)methyl]-(125552-98-9)
• EPA Substance Registry System: Benzamide, N-[(2-methylphenyl)methyl]-(125552-98-9)

Safety Data

• Hazardous Substances Data: 125552-98-9(Hazardous Substances Data)

Upstream product

• 89-93-0 ortho-methylbenzylamine 
• 98-88-4 benzoyl chloride 
• 95-47-6 o-xylene 
• 100-47-0 benzonitrile 
• 15018-12-9 2-methoxymethyltoluene 
• 17373-93-2 2-methylbenzyl acetate 
• 89-92-9 2-methylbenzyl bromide 
• 529-20-4 2-methylphenyl aldehyde 
• 35629-84-6 N'-(2-methylbenzylidene)-4-methylbenzenesulfonohydrazide 
• 55-21-0 benzamide 
• 89-95-2 2-methyl-benzyl alcohol 
• 95-49-8 2-methylchlorobenzene 
• 529-19-1 2-Methylbenzonitrile 

Downstream Products

• 18913-39-8 isoindolin-2-yl(phenyl)methanone 

Relevant articles and documents

Convenient synthesis of amides by Zn(ClO4)2·6H2O catalysed Ritter reaction with nitriles and halohydrocarbons

A convenient and high yielding procedure for the synthesis of amides by the Ritter reaction of nitriles and halohydrocarbons in the presence of Zn(ClO4)2·6H2O as a highly stable, effective and available catalyst is described.

FeCl2·4H2O catalyzed ritter reaction with nitriles and halohydrocarbons

An efficient and inexpensive synthesis of N-substituted amides from the Ritter reaction of nitriles with various halohydrocarbons catalyzed by FeCl2·4H2O is described. FeCl2·4H2O economically efficiently catalyzed the Ritter reaction under solvent-free conditions. A range of halohydrocarbons (benzyl, tert-butyl and sec-alkyl halohydrocarbons) were coupled with nitriles to provide the corresponding amides in high to excellent yields.

Acetonitrile and benzonitrile as versatile amino sources in copper-catalyzed mild electrochemical C-H amidation reactions

A mild, efficient electrochemical approach to the site-selective direct C-H amidation of benzene and its derivatives with acetonitrile and benzonitrile has been developed. It has been shown that joint electrochemical oxidation of various arenes in the presence of a copper salt as a catalyst and nitriles leads to the formation of N-phenylacetamide from benzene and N-benzylacetamides from benzyl derivatives (up to 78% yield). A favorable feature of the process is mild conditions (room temperature, ambient pressure, no strong oxidants) that meet the criteria of green chemistry.

An efficient transformation of methyl ethers and nitriles to amides catalyzed by Iron(III) perchlorate hydrate

An efficient and inexpensive synthesis of N-substituted amides from the reaction of nitriles with methyl ethers catalyzed by Fe(ClO4)3·H2O is described. Fe(ClO4)3·H2O is an economically efficient catalyst for the Ritter Reaction under solvent-free conditions. A range of methyl ethers (benzyl, sec-alkyl and tert-butyl ethers) were reacted with nitriles to provide the corresponding amides in high–excellent yields.