1255651-84-3

Upstream product

• 108-46-3 recorcinol 
• 1255651-99-0 (2R,2'R)-dimethyl 2,2'-((2-iodo-1,3-phenylene)bis(oxy))dipropanoate 
• 64-19-7 acetic acid 
• 41046-67-7 2-iodoresorcinol 
• 79-21-0 peracetic acid 

Downstream Products

• 1226896-33-8 (2R,2′R)-2,2′-((2-iodo-1,3-phenylene)bis(oxy))dipropanoic acid 
• 1226896-38-3 (2R,2'R)-2,2'-((2-iodo-1,3-phenylene)bis(oxy))bis(N-mesitylpropanamide) 
• 1226896-63-4 (2,6-bis(((R)-1-(mesitylamino)-1-oxopropan-2-yl)oxy)-phenyl)-λ³-iodanediyl diacetate 
• 1291104-97-6 (S)-1,2-diacetoxy-1-(2,6-difluorophenyl)ethane 
• 1291105-03-7 (R)-1,2-diacetoxy-1-(2,6-difluorophenyl)ethane 
• 1291105-05-9 (R)-1-(2-chlorophenyl)ethane-1,2-diol-1,2-diacetate 
• 1291104-98-7 (S)-1-(2-chlorophenyl)ethane-1,2-diol-1,2-diacetate 
• 78692-90-7 (R)-2-methylcarbonyloxy-1-phenylethyl acetate 
• 147256-19-7 (S)-2-methylcarbonyloxy-1-phenylethyl acetate 

Relevant academic research and scientific papers

Hypervalent Iodine(III)-Catalysed Enantioselective α-Acetoxylation of Ketones

An enantioselective catalytic synthesis of α-acetoxylated ketones through I(I)/I(III) catalysis using a resorcinol/lactamide-based chiral iodoarene is reported. Catalyst turnover by in situ generation of the active iodine(III) derivative is achieved by oxidation with mCPBA in the presence of acetic acid. The prior transformation of ketones to easily accessible acetyl enol ethers is beneficial and yields up to 97 percent with enantioselectivities up to 88 percent ee are obtained using only low catalyst loadings of only 5 mol percent under mild reaction conditions.

Electron-Deficient Chiral Lactic Acid-Based Hypervalent Iodine Reagents

Novel electron-deficient chiral hypervalent iodine reagents were prepared in good overall yields. The reactivity and stereoselectivity of these reagents in oxidative rearrangements of alkenes to α-aryl ketones were investigated. The results show that the new reagents have good reactivity and generate products with high enantiomeric excess.

Stereoselective Ketone Rearrangements with Hypervalent Iodine Reagents

The first stereoselective version of an iodine(III)-mediated rearrangement of arylketones in the presence of orthoesters is described. The reaction products, α-arylated esters, are very useful intermediates in the synthesis of bioactive compounds such as ibuprofen. With chiral lactic acid-based iodine(III) reagents product selectivities of up to 73 % ee have been achieved.

Enantiodifferentiating endo-selective oxylactonization of ortho-alk-l-enylbenzoate with a lactate-derived aryl-λ3-iodane

It's the hype: The asymmetric synthesis of 3-alkyl-4-oxyisochroman-1-one is achieved by oxylactonization of ortho-alk-1-enylbenzoate with a series of optically active hypervalent iodine(III) reagents prepared from lactate or valine as a chiral source (see scheme). The oxylactonization is highly regio-, diastereo-, and enantioselective. 2010 Wiley-VCH Verlag GmbH & Co. KGaA.