1255790-64-7Relevant articles and documents
Synthesis and evaluation of in vitro antitubercular activity and antimicrobial activity of some novel 4H-chromeno[2,3-d] pyrimidine via 2-amino-4-phenyl-4H-chromene-3-carbonitriles
Kamdar, Nimesh R.,Haveliwala, Dhaval D.,Mistry, Prashant T.,Patel, Saurabh K.
, p. 854 - 864 (2012/05/20)
Novel 5-phenyl-1,5-dihydro-2H-chromeno[2,3- d]pyrimidine-2,4(3H)-dithiones, 5-phenyl-3,5-dihydro-4Hchromeno[ 2,3-d]pyrimidin-4-ones, 7-phenyl-7,9-dihydro- 8H pyrimido[5',4':5,6]pyrano[3,2-h]quinolin-8-ones, and 4- amino-5-phenyl-1,5- dihydro-2H-chromeno[2,3-d]pyrimidine- 2-thiones were synthesized form 2-amino-4-phenyl-4Hchromene- 3-carbonitrile. The newly synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, Mass spectra, and Elemental analysis. The compounds were evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv and antibacterial activity against Staphylococcus Aureus [ATCC-25923] and Streptococcus pyogenes [MTCC-443] as Gram-positive, Escherichia coli [ATCC-25922], and Pseudomonas aeruginosa [MTCC-441] as Gram-negative bacterial strains and antifungal activity against Aspergillus niger [MTCC-282]. Some of these derivatives exhibited pronounced antitubercular and antimicrobial activities. Springer Science+Business Media, LLC 2010.
