1255792-05-2

Basic information

• Product Name: 1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-ol
• Synonyms: 1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-ol
• CAS NO: 1255792-05-2
• Molecular Weight: 251.239
• Mol File: 1255792-05-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-ol(1255792-05-2)
• EPA Substance Registry System: 1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-ol(1255792-05-2)

Safety Data

• Hazardous Substances Data: 1255792-05-2(Hazardous Substances Data)

Usage

Chemical structure

A complex organic molecule with a phenyl ring, a nitro group, a methoxy group, a prop-2-yn-1-yloxy group, and an ethan-1-ol group.

Functional groups

Nitro (-NO2), methoxy (-OCH3), prop-2-yn-1-yloxy (-OC≡CH), and hydroxyl (-OH).

Potential applications

Organic synthesis and medicinal chemistry.

Further research needed

To determine specific uses and potential applications in pharmaceuticals or materials development.

Structural complexity

Requires further study and testing to draw conclusions about its properties and potential applications.

Upstream product

• 5651-83-2 3-methoxy-4-(prop-2-ynyloxy)benzaldehyde 
• 75-24-1 trimethylaluminum 
• 6100-74-9 3-hydroxy-4-methoxyacetophenone 
• 956597-80-1 1-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 1255792-04-1 1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one 

Downstream Products

• 1456901-32-8 1-(5-methoxy-2-nitro-4-prop-2-ynyloxyphenyl)ethyl bromide 
• 1255792-08-5 3-(2-methoxy-5-nitro-4-(1-(oxabicyclo[2,2,1]hept-5-enedicarboxyimide)ethyl)phenoxy)-1-propyne 
• 1456901-35-1 2-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione 
• 1456901-37-3 1-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-1H-pyrrole-2,5-dione 
• 1456901-39-5 1-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-3-(octylthio)pyrrolidine-2,5-dione 

Relevant articles and documents

Cellular delivery and photochemical activation of antisense agents through a nucleobase caging strategy

Antisense oligonucleotides are powerful tools to regulate gene expression in cells and model organisms. However, a transfection or microinjection is typically needed for efficient delivery of the antisense agent. We report the conjugation of multiple HIV TAT peptides to a hairpin-protected antisense agent through a light-cleavable nucleobase caging group. This conjugation allows for the facile delivery of the antisense agent without a transfection reagent, and photochemical activation offers precise control over gene expression. The developed approach is highly modular, as demonstrated by the conjugation of folic acid to the caged antisense agent. This enabled targeted cell delivery through cell-surface folate receptors followed by photochemical triggering of antisense activity. Importantly, the presented strategy delivers native oligonucleotides after light-activation, devoid of any delivery functionalities or modifications that could otherwise impair their antisense activity.

For the control of the chimeric antigen receptor of the T cell activation/inhibit the connecting arm and its application (by machine translation)

The invention discloses a method for control CAR - T/inhibit the activation of the link arm, and one end of the cells containing the target [...] molecule, the other at one end and can be specific CAR - T cell identified with biological orthogonality of the part, and the middle of the can be biological orthogonal fracture chemical group coupling. This invention can realize the CAR - T cell from active to a resting state fast and flexible conversion, to CAR - T cell inhibiting the systematic and high efficiency. Adjusting has reversibility, not damage or kill some CAR - T cell, can realize the CAR - T cell from active to close and then to activate the flexible change, the overall functions of the treatment is not affected. (by machine translation)

A heterobifunctional linker bearing azide-reactive alkyne and thiol-reactive maleimide connected with N-(2-Nitrobenzyl)imide to synthesize photocleavable diblock copolymers

A novel heterobifunctional linker 1 connected with photocleavable N-(2-nitrobenzyl)imide has been developed. Hydrophobic polystyrene (PS), hydrophilic poly(ethylene oxide) (PEO), and thermosensitive poly(N- isopropylacrylamide) (PNIPAM) containing thiol or azide at the terminal, synthesized by a living radical polymerization or a transformation of terminal functional groups, were coupled with the alkyne and maleimide protected as the furan adduct at both terminals of 1 to synthesize three types of photocleavable diblock copolymers in high yields.