1256276-24-0

Upstream product

• 1403332-43-3 ethyl 2-(1-ethoxyvinyl)oxazole-4-carboxylate 
• 177760-52-0 ethyl 2-aminooxazole-4-carboxylate 
• 460081-18-9 ethyl 2-chloro-1,3-oxazole-4-carboxylate 
• 1256276-23-9 ethyl (E)-2-(1-phenylprop-1-en-2-yl)oxazole-4-carboxylate 
• 1333145-73-5 C₂₄H₂₉NO₄Si 
• 1333145-72-4 C₂₄H₃₁NO₄Si 
• 1333145-71-3 C₂₄H₃₃NO₅Si 
• 1333145-74-6 C₈H₁₁NO₄ 

Downstream Products

• 1333145-83-7 C₃₄H₅₂N₄O₈ 
• 1333145-85-9 C₂HF₃O₂*C₂₉H₄₄N₄O₆ 
• 1333145-86-0 C₃₆H₅₅N₅O₇ 
• 1333145-70-2 C₃₇H₅₅N₅O₈ 
• 1297546-07-6 (S)-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(2-hydroxypropan-2-yl)oxazole-4-carboxamide 
• 1403333-72-1 (S)-N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-2-(2-propen-2-yl)oxazole-4-carboxamide 
• 1403334-62-2 (S)-N-(1-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(2-hydroxypropan-2-yl)oxazole-4-carboxamide 
• 1403334-63-3 (S)-N-(2-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propyl)-2-(2-hydroxypropan-2-yl)oxazole-4-carboxamide 
• 1403334-64-4 (R)-N-(2-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propyl)-2-(2-hydroxypropan-2-yl)oxazole-4-carboxamide 

Relevant academic research and scientific papers

ANDROGEN RECEPTOR MODULATING CARBOXAMIDES

Compounds of formula (I) or (II) wherein Rx, Rz, R9, R10, R14, R14′, R15, R15′, A and B are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds possess utility as tissue-selective androgen receptor modulators (SARM) and are useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.

ANDROGEN RECEPTOR MODULATING CARBOXAMIDES

Compounds of formula (I) wherein Rx, Rz, R9, R10, R14, R14', R15, R15', A and B are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds possess utility as tissue-selective androgen receptor modulators (SARM) and are particularly useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.

Total synthesis and cytotoxicity evaluation of an oxazole analogue of tubulysin U

Tubulysins are strongly cytotoxic natural tetrapeptides with potent antiproliferative, antimitotic, and antiangiogenic activities which might find use in oncology. We herein report the first total synthesis of a stereoisomerically pure oxazole analogue of

FLUORINATED AMINOTRIAZOLE DERIVATIVES

The invention relates to fluorinated aminotriazole derivatives of formula (I), wherein A, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.