460081-18-9

Basic information

• Product Name: ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE
• Synonyms: 2-CHLOROOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER, 95+%;Ethyl 2-chlorooxazole-4-c...;2-Chloro-1,3-Oxazole-4-Carboxylic Acid Ethylester;4-Oxazolecarboxylic acid, 2-chloro-, ethyl ester;ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE;2-CHLOROOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;Ethyl 2-chloro-1,3-oxazole-4-carboxylate;4-Oxazolecarboxylicacid,2-chloro-,ethylester(9CI)
• CAS NO: 460081-18-9
• Molecular Formula: C₆H₆ClNO₃
• Molecular Weight: 175.57
• Product Categories: Carboxes;Oxazoles;THIAZOLE;blocks
• Mol File: 460081-18-9.mol
• Article Data: 18

Chemical Properties

• Melting Point: 97-98℃
• Boiling Point: 254.1°C at 760 mmHg
• Flash Point: 107.5°C
• Appearance: /
• Density: 1.332g/cm³
• Vapor Pressure: 0.0176mmHg at 25°C
• Refractive Index: 1.487
• Storage Temp.: Keep Cold
• PKA: -3.20±0.10(Predicted)
• CAS DataBase Reference: ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE(460081-18-9)
• EPA Substance Registry System: ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE(460081-18-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 460081-18-9(Hazardous Substances Data)

Usage

General Description

ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE is a chemical compound with the molecular formula C7H6ClNO3. It is a clear, colorless liquid at room temperature and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in the production of various organic compounds. The presence of the chlorooxazole and carboxylate functional groups makes this compound a versatile building block in organic chemistry, allowing for a wide range of potential applications.ETHYL 2-CHLOROOXAZOLE-4-CARBOXYLATE.

InChI:InChI=1/C6H6ClNO3/c1-2-10-5(9)4-3-11-6(7)8-4/h3H,2H2,1H3

Upstream product

• 540-80-7 tert.-butylnitrite 
• 177760-52-0 ethyl 2-aminooxazole-4-carboxylate 
• 7447-39-4 copper(II) chloride 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 1030613-60-5 Ethyl-2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3-oxazole-4-carboxylate 
• 460081-24-7 2-vinyloxazole-4-carboxylic acid ethyl ester 
• 78979-61-0 ethyl 2-(4-methoxyphenyl)-1,3-oxazole-4-carboxylate 
• 1357944-10-5 ethyl 2-[4-(trifluoromethyl)phenyl]oxazole-4-carboxylate 
• 132089-42-0 ethyl 2-(4-fluorophenyl)-1,3-oxazole-4-carboxylate 
• 460081-20-3 2-bromo-4-(ethoxycarbonyl)-1,3-oxazol-5-ylium 
• 885274-61-3 2-o-tolyloxazole-4-carboxylic acid ethyl ester 
• 1256276-24-0 ethyl 2-acetyloxazole-4-carboxylate 
• 1557037-79-2 2-(4-cyano-2-fluoro-phenyl)-oxazole-4-carboxylic acid ethyl ester 
• 1392426-91-3 ethyl 2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-oxazole-4-carboxylate 

Relevant articles and documents

Deaminative chlorination of aminoheterocycles

Selective modification of heteroatom-containing aromatic structures is in high demand as it permits rapid evaluation of molecular complexity in advanced intermediates. Inspired by the selectivity of deaminases in nature, herein we present a simple methodology that enables the NH2 groups in aminoheterocycles to be conceived as masked modification handles. With the aid of a simple pyrylium reagent and a cheap chloride source, C(sp2)?NH2 can be converted into C(sp2)?Cl bonds. The method is characterized by its wide functional group tolerance and substrate scope, allowing the modification of >20 different classes of heteroaromatic motifs (five- and six-membered heterocycles), bearing numerous sensitive motifs. The facile conversion of NH2 into Cl in a late-stage fashion enables practitioners to apply Sandmeyer- and Vilsmeier-type transforms without the burden of explosive and unsafe diazonium salts, stoichiometric transition metals or highly oxidizing and unselective chlorinating agents. [Figure not available: see fulltext.]

NOVEL QUINOLINONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ALLERGIC DISEASES SUCH AS ASTHMA OR ATOPIC DERMATITIS INCLUDING THE QUINOLINONE DERIVATIVE AS ACTIVE INGREDIENT

The present invention relates to anovel quinolinone derivative compound that regulates intracellular signal transduction mediated by TSLP and IL-33 to exhibit efficacy in preventing or treating allergic diseases such as asthma or atopic dermatitis. The qu

Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms)

Lipoxins (LXs) are endogenously generated eicosanoids with potent bio-actions consistent with attenuation of inflammation. The costly synthesis and metabolic instability of LXs may limit their therapeutic potential. Here we report the synthesis and charac