125630-28-6Relevant articles and documents
Imine salt derivative, preparation method thereof and preparation method of nicotine
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Paragraph 0089-0091; 0093, (2020/01/12)
The invention discloses an imine salt derivative, a preparation method thereof and a preparation method of nicotine. The preparation method of nicotine includes the steps of: adding an imine salt derivative shown as general formula (I) or (II) in the specification and a reducing agent into a solvent for reaction to prepare a racemic nicotine solution; adding a second quenching agent into the racemic nicotine solution to obtain a nicotine precursor solution; and adding an extracting agent into the nicotine precursor solution, conducting reduced pressure concentration, and performing drying andremoving the solvent, thus obtaining nicotine. According to the invention, through the imine salt derivative intermediate synthesized for the first time and the use of the cheap reducing agent, the intermediate is reduced under a relatively mild condition to obtain racemic nicotine. Compared with the existing nicotine synthesis process, the method has the advantages of mild synthesis process conditions, simple equipment requirement, high product purity and high synthesis rate, and is particularly suitable for industrial production.
A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines
Dunsmore, Colin J.,Carr, Reuben,Fleming, Toni,Turner, Nicholas J.
, p. 2224 - 2225 (2007/10/03)
Deracemization of racemic chiral tertiary amines has been achieved by combination of an enantioselective amine oxidase, obtained through directed evolution, and ammonia borane in a one-pot process. Copyright
