125630-28-6Relevant academic research and scientific papers
Imine salt derivative, preparation method thereof and preparation method of nicotine
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Paragraph 0089-0091; 0093, (2020/01/12)
The invention discloses an imine salt derivative, a preparation method thereof and a preparation method of nicotine. The preparation method of nicotine includes the steps of: adding an imine salt derivative shown as general formula (I) or (II) in the specification and a reducing agent into a solvent for reaction to prepare a racemic nicotine solution; adding a second quenching agent into the racemic nicotine solution to obtain a nicotine precursor solution; and adding an extracting agent into the nicotine precursor solution, conducting reduced pressure concentration, and performing drying andremoving the solvent, thus obtaining nicotine. According to the invention, through the imine salt derivative intermediate synthesized for the first time and the use of the cheap reducing agent, the intermediate is reduced under a relatively mild condition to obtain racemic nicotine. Compared with the existing nicotine synthesis process, the method has the advantages of mild synthesis process conditions, simple equipment requirement, high product purity and high synthesis rate, and is particularly suitable for industrial production.
PROCESS FOR PREPARING RACEMIC NICOTINE
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, (2014/02/16)
Provided is a process for preparing racemic nicotine from 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof using one-pot process. The process comprises the following steps: 1) in a reaction vessel, reacting 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof in the presence of a suitable solvent and a strong acid by heat; after the reaction is complete, cooling the same and adjusting the pH to 7-8 with alkali; and 2) directly adding a reductant into the above vessel, and after the reaction, purifying the product so as to obtain high purity racemic nicotine or a salt thereof.
A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines
Dunsmore, Colin J.,Carr, Reuben,Fleming, Toni,Turner, Nicholas J.
, p. 2224 - 2225 (2007/10/03)
Deracemization of racemic chiral tertiary amines has been achieved by combination of an enantioselective amine oxidase, obtained through directed evolution, and ammonia borane in a one-pot process. Copyright
Synthesis of [4-2H2]-, (4R)[4-2H1]-and (4S)[4-2H1]- 4-(methylnitrosamino)-1 -(3′-pyridyl)-1-butanone, c-4 deuteriated isotopomers of the procarcinogen nnk
Pathak, Tanmaya,Thomas, Noel F.,Akhtar, Mahmoud,Gani, David
, p. 1733 - 1744 (2007/10/02)
The synthesis of C-4 dideuteriated and both C-4 monodeuteriated enantiomers of NNK, the metabolic precursor to a variety of potential carcinogens, starting from (2S)-glutamic acid and nicotinic acid is described. The route is suitable for the synthesis of NNK isotopomers labelled in each of the putative sites for metabolic activation.
