348640-11-9

Basic information

• Product Name: 3-BROMO-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 3-BROMO-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;3-BROMO-5-METHOXYINDOLE, N-BOC PROTECTED;3-Bromo-5-methoxyindole, N-BOC protected 98%;1-Boc-3-bromo-5-methoxyindole;Zinc02563778;tert-butyl 3-bromo-5-methoxy-1H-indole-1-carboxylate;3-Bromo-5-methoxyindole,N-BOCprotected98%;tert-butyl 3-bromo-5-methoxy-indole-1-carboxylate
• CAS NO: 348640-11-9
• Molecular Formula: C₁₄H₁₆BrNO₃
• Molecular Weight: 326.19
• Mol File: 348640-11-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 403.846 °C at 760 mmHg
• Flash Point: 198.039 °C
• Appearance: /
• Density: 1.379 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-BROMO-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(348640-11-9)
• EPA Substance Registry System: 3-BROMO-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(348640-11-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 348640-11-9(Hazardous Substances Data)

Usage

General Description

3-Bromo-5-Methoxyindole-1-Carboxylic Acid Tert-Butyl Ester is a chemical compound that belongs to the class of organic compounds known as indoles. It is a tert-butyl ester of 3-bromo-5-methoxyindole-1-carboxylic acid, which is a carboxylic acid derivative obtained by the formal condensation of the carboxy group of 3-bromo-5-methoxyindole-1-carboxylic acid with tert-butanol. It is a white to light brown powder with a molecular formula of C15H16BrNO3 and a molecular weight of 336.197 g/mol. 3-BROMO-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used in chemical research and synthesis processes and may have potential pharmaceutical applications.

InChI:InChI=1/C14H16BrNO3/c1-14(2,3)19-13(17)16-8-11(15)10-7-9(18-4)5-6-12(10)16/h5-8H,1-4H3

Upstream product

• 1006-94-6 5-methoxylindole 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 348640-51-7 2-(1-tert-Butyloxycarbonyl-5-methoxy-1H-indol-3-yl)-4-methoxy-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 1350378-16-3 tert-butyl 3-(5-fluoro-4-(2-(1-hydroxycyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-5-methoxy-1H-indole-1-carboxylate 
• 1256359-99-5 tert-butyl 5-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-indole-1-carboxylate 
• 348640-19-7 C₁₄H₁₈BNO₅ 

Relevant articles and documents

Azaindoles

The invention is directed to compositions containing physiologically active compounds of general formula (I): wherein R1 is aryl or heteroaryl; R2 represents hydrogen, acyl, cyano, halo, lower alkenyl or lower alkyl optionally substituted by a substituent selected from cyano, heteroaryl, heterocycloalkyl, —Z1R8, —C(═O)—NY3Y4, —CO2R8, —NY3Y4, —N(R6)—C(═O)—R7, —N(R6)—C(═O)—NY3Y4, —N(R6)—C(═O)—OR7, —N(R6)—SO2—R7, —N(R6)—SO2—NY3Y4 and one or more halogen a toms ; R3 represents hydrogen, aryl, cyano, halo, heteroaryl, lower alkyl, —C(═O)—OR5 or —C(═O)—NY3Y; and X1 represents N, CH, C-halo, C—CN, C—R7, C—NY3Y4, C—OH, C—Z2R7, C—C(═O)—OR5, C—C(═O)—NY3Y4, C—N(R8)—C(═O)—R7, C—SO2—NY3Y4, C—N(R8)—SO2—R7, C-alkenyl, C-alkynyl or C—NO2; and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (I). Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit protein kinases.